Inactivation of CBF/NF-Y in postnatal liver causes hepatocellular degeneration, lipid deposition, and endoplasmic reticulum stress

We previously demonstrated that CBF activity is needed for cell proliferation and early embryonic development. To examine the in vivo function of CBF in differentiated hepatocytes, we conditionally deleted CBF-B in hepatocytes after birth. Deletion of CBF-B resulted in progressive liver injury and s...

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Detalles Bibliográficos
Autores principales: Luo, Rong, Klumpp, Sherry A., Finegold, Milton J., Maity, Sankar N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216617/
https://www.ncbi.nlm.nih.gov/pubmed/22355653
http://dx.doi.org/10.1038/srep00136

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