Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study

The safety and effectiveness of tetrabenazine in different sub-populations of Huntington disease (HD) is not known. In this study, we evaluated the safety of tetrabenazine in individuals on an antidepressant and its effectiveness in advanced HD. Tetrabenazine was not associated with an increased inc...

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Detalles Bibliográficos
Autores principales: Dorsey, Ray, Biglan, Kevin, Eberly, Shirley, Auinger, Peggy, Brocht, Alicia, Umeh, Chizoba C., Oakes, David, Clarence-Smith, Kathleen, Marshall, Frederick, Shoulson, Ira, Frank, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Huntington Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216756/
https://www.ncbi.nlm.nih.gov/pubmed/22139861
http://dx.doi.org/10.1371/currents.RRN1283
Descripción
Sumario:The safety and effectiveness of tetrabenazine in different sub-populations of Huntington disease (HD) is not known. In this study, we evaluated the safety of tetrabenazine in individuals on an antidepressant and its effectiveness in advanced HD. Tetrabenazine was not associated with an increased incidence of depressed mood among those taking antidepressants and was effective at reducing chorea in those with advanced HD.

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