Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study

The safety and effectiveness of tetrabenazine in different sub-populations of Huntington disease (HD) is not known. In this study, we evaluated the safety of tetrabenazine in individuals on an antidepressant and its effectiveness in advanced HD. Tetrabenazine was not associated with an increased inc...

Descripción completa

Detalles Bibliográficos
Autores principales: Dorsey, Ray, Biglan, Kevin, Eberly, Shirley, Auinger, Peggy, Brocht, Alicia, Umeh, Chizoba C., Oakes, David, Clarence-Smith, Kathleen, Marshall, Frederick, Shoulson, Ira, Frank, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Huntington Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216756/
https://www.ncbi.nlm.nih.gov/pubmed/22139861
http://dx.doi.org/10.1371/currents.RRN1283
_version_ 1782216554807558144
author Dorsey, Ray
Biglan, Kevin
Eberly, Shirley
Auinger, Peggy
Brocht, Alicia
Umeh, Chizoba C.
Oakes, David
Clarence-Smith, Kathleen
Marshall, Frederick
Shoulson, Ira
Frank, Samuel
author_facet Dorsey, Ray
Biglan, Kevin
Eberly, Shirley
Auinger, Peggy
Brocht, Alicia
Umeh, Chizoba C.
Oakes, David
Clarence-Smith, Kathleen
Marshall, Frederick
Shoulson, Ira
Frank, Samuel
author_sort Dorsey, Ray
collection PubMed
description The safety and effectiveness of tetrabenazine in different sub-populations of Huntington disease (HD) is not known. In this study, we evaluated the safety of tetrabenazine in individuals on an antidepressant and its effectiveness in advanced HD. Tetrabenazine was not associated with an increased incidence of depressed mood among those taking antidepressants and was effective at reducing chorea in those with advanced HD.
format Online
Article
Text
id pubmed-3216756
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-32167562011-12-02 Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study Dorsey, Ray Biglan, Kevin Eberly, Shirley Auinger, Peggy Brocht, Alicia Umeh, Chizoba C. Oakes, David Clarence-Smith, Kathleen Marshall, Frederick Shoulson, Ira Frank, Samuel PLoS Curr Huntington Disease The safety and effectiveness of tetrabenazine in different sub-populations of Huntington disease (HD) is not known. In this study, we evaluated the safety of tetrabenazine in individuals on an antidepressant and its effectiveness in advanced HD. Tetrabenazine was not associated with an increased incidence of depressed mood among those taking antidepressants and was effective at reducing chorea in those with advanced HD. Public Library of Science 2011-11-13 /pmc/articles/PMC3216756/ /pubmed/22139861 http://dx.doi.org/10.1371/currents.RRN1283 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Huntington Disease
Dorsey, Ray
Biglan, Kevin
Eberly, Shirley
Auinger, Peggy
Brocht, Alicia
Umeh, Chizoba C.
Oakes, David
Clarence-Smith, Kathleen
Marshall, Frederick
Shoulson, Ira
Frank, Samuel
Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study
title Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study
title_full Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study
title_fullStr Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study
title_full_unstemmed Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study
title_short Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study
title_sort use of tetrabenazine in huntington disease patients on antidepressants or with advanced disease: results from the tetra-hd study
topic Huntington Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216756/
https://www.ncbi.nlm.nih.gov/pubmed/22139861
http://dx.doi.org/10.1371/currents.RRN1283
work_keys_str_mv AT dorseyray useoftetrabenazineinhuntingtondiseasepatientsonantidepressantsorwithadvanceddiseaseresultsfromthetetrahdstudy
AT biglankevin useoftetrabenazineinhuntingtondiseasepatientsonantidepressantsorwithadvanceddiseaseresultsfromthetetrahdstudy
AT eberlyshirley useoftetrabenazineinhuntingtondiseasepatientsonantidepressantsorwithadvanceddiseaseresultsfromthetetrahdstudy
AT auingerpeggy useoftetrabenazineinhuntingtondiseasepatientsonantidepressantsorwithadvanceddiseaseresultsfromthetetrahdstudy
AT brochtalicia useoftetrabenazineinhuntingtondiseasepatientsonantidepressantsorwithadvanceddiseaseresultsfromthetetrahdstudy
AT umehchizobac useoftetrabenazineinhuntingtondiseasepatientsonantidepressantsorwithadvanceddiseaseresultsfromthetetrahdstudy
AT oakesdavid useoftetrabenazineinhuntingtondiseasepatientsonantidepressantsorwithadvanceddiseaseresultsfromthetetrahdstudy
AT clarencesmithkathleen useoftetrabenazineinhuntingtondiseasepatientsonantidepressantsorwithadvanceddiseaseresultsfromthetetrahdstudy
AT marshallfrederick useoftetrabenazineinhuntingtondiseasepatientsonantidepressantsorwithadvanceddiseaseresultsfromthetetrahdstudy
AT shoulsonira useoftetrabenazineinhuntingtondiseasepatientsonantidepressantsorwithadvanceddiseaseresultsfromthetetrahdstudy
AT franksamuel useoftetrabenazineinhuntingtondiseasepatientsonantidepressantsorwithadvanceddiseaseresultsfromthetetrahdstudy

Ejemplares similares