Galectin-3 Mediates Cross-Talk between K-Ras and Let-7c Tumor Suppressor microRNA

BACKGROUND: Galectin-3 (Gal-3) and active (GTP-bound) K-Ras contribute to the malignant phenotype of many human tumors by increasing the rate of cell proliferation, survival, and migration. These Gal-3-mediated effects result from a selective binding to K-Ras.GTP, causing increased nanoclustering in...

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Detalles Bibliográficos
Autores principales: Levy, Ran, Biran, Anat, Poirier, Francoise, Raz, Avraham, Kloog, Yoel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216962/
https://www.ncbi.nlm.nih.gov/pubmed/22102901
http://dx.doi.org/10.1371/journal.pone.0027490

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