Darinaparsin Is a Multivalent Chemotherapeutic Which Induces Incomplete Stress Response with Disruption of Microtubules and Shh Signaling

Chemotherapeutics and other pharmaceuticals are common sources of cellular stress. Darinaparsin (ZIO-101) is a novel organic arsenical under evaluation as a cancer chemotherapeutic, but the drug's precise mechanism of action is unclear. Stress granule formation is an important cellular stress r...

Descripción completa

Detalles Bibliográficos
Autores principales: Mason, Twila A., Kolobova, Elena, Liu, Jiang, Roland, Joseph T., Chiang, Chin, Goldenring, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216988/
https://www.ncbi.nlm.nih.gov/pubmed/22110729
http://dx.doi.org/10.1371/journal.pone.0027699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216988/
https://www.ncbi.nlm.nih.gov/pubmed/22110729
http://dx.doi.org/10.1371/journal.pone.0027699

Ejemplares similares