Epigenetic Regulation of miR-212 Expression in Lung Cancer

Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by invest...

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Autores principales: Incoronato, Mariarosaria, Urso, Loredana, Portela, Ana, Laukkanen, Mikko O., Soini, Ylermi, Quintavalle, Cristina, Keller, Simona, Esteller, Manel, Condorelli, Gerolama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216999/
https://www.ncbi.nlm.nih.gov/pubmed/22110741
http://dx.doi.org/10.1371/journal.pone.0027722
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author Incoronato, Mariarosaria
Urso, Loredana
Portela, Ana
Laukkanen, Mikko O.
Soini, Ylermi
Quintavalle, Cristina
Keller, Simona
Esteller, Manel
Condorelli, Gerolama
author_facet Incoronato, Mariarosaria
Urso, Loredana
Portela, Ana
Laukkanen, Mikko O.
Soini, Ylermi
Quintavalle, Cristina
Keller, Simona
Esteller, Manel
Condorelli, Gerolama
author_sort Incoronato, Mariarosaria
collection PubMed
description Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.
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spelling pubmed-32169992011-11-21 Epigenetic Regulation of miR-212 Expression in Lung Cancer Incoronato, Mariarosaria Urso, Loredana Portela, Ana Laukkanen, Mikko O. Soini, Ylermi Quintavalle, Cristina Keller, Simona Esteller, Manel Condorelli, Gerolama PLoS One Research Article Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease. Public Library of Science 2011-11-15 /pmc/articles/PMC3216999/ /pubmed/22110741 http://dx.doi.org/10.1371/journal.pone.0027722 Text en Incoronato et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Incoronato, Mariarosaria
Urso, Loredana
Portela, Ana
Laukkanen, Mikko O.
Soini, Ylermi
Quintavalle, Cristina
Keller, Simona
Esteller, Manel
Condorelli, Gerolama
Epigenetic Regulation of miR-212 Expression in Lung Cancer
title Epigenetic Regulation of miR-212 Expression in Lung Cancer
title_full Epigenetic Regulation of miR-212 Expression in Lung Cancer
title_fullStr Epigenetic Regulation of miR-212 Expression in Lung Cancer
title_full_unstemmed Epigenetic Regulation of miR-212 Expression in Lung Cancer
title_short Epigenetic Regulation of miR-212 Expression in Lung Cancer
title_sort epigenetic regulation of mir-212 expression in lung cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216999/
https://www.ncbi.nlm.nih.gov/pubmed/22110741
http://dx.doi.org/10.1371/journal.pone.0027722
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