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Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer
Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217025/ https://www.ncbi.nlm.nih.gov/pubmed/22110403 http://dx.doi.org/10.1371/journal.pbio.1001199 |
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author | Maxwell, Christopher A. Benítez, Javier Gómez-Baldó, Laia Osorio, Ana Bonifaci, Núria Fernández-Ramires, Ricardo Costes, Sylvain V. Guinó, Elisabet Chen, Helen Evans, Gareth J. R. Mohan, Pooja Català, Isabel Petit, Anna Aguilar, Helena Villanueva, Alberto Aytes, Alvaro Serra-Musach, Jordi Rennert, Gad Lejbkowicz, Flavio Peterlongo, Paolo Manoukian, Siranoush Peissel, Bernard Ripamonti, Carla B. Bonanni, Bernardo Viel, Alessandra Allavena, Anna Bernard, Loris Radice, Paolo Friedman, Eitan Kaufman, Bella Laitman, Yael Dubrovsky, Maya Milgrom, Roni Jakubowska, Anna Cybulski, Cezary Gorski, Bohdan Jaworska, Katarzyna Durda, Katarzyna Sukiennicki, Grzegorz Lubiński, Jan Shugart, Yin Yao Domchek, Susan M. Letrero, Richard Weber, Barbara L. Hogervorst, Frans B. L. Rookus, Matti A. Collee, J. Margriet Devilee, Peter Ligtenberg, Marjolijn J. van der Luijt, Rob B. Aalfs, Cora M. Waisfisz, Quinten Wijnen, Juul van Roozendaal, Cornelis E. P. Easton, Douglas F. Peock, Susan Cook, Margaret Oliver, Clare Frost, Debra Harrington, Patricia Evans, D. Gareth Lalloo, Fiona Eeles, Rosalind Izatt, Louise Chu, Carol Eccles, Diana Douglas, Fiona Brewer, Carole Nevanlinna, Heli Heikkinen, Tuomas Couch, Fergus J. Lindor, Noralane M. Wang, Xianshu Godwin, Andrew K. Caligo, Maria A. Lombardi, Grazia Loman, Niklas Karlsson, Per Ehrencrona, Hans von Wachenfeldt, Anna Bjork Barkardottir, Rosa Hamann, Ute Rashid, Muhammad U. Lasa, Adriana Caldés, Trinidad Andrés, Raquel Schmitt, Michael Assmann, Volker Stevens, Kristen Offit, Kenneth Curado, João Tilgner, Hagen Guigó, Roderic Aiza, Gemma Brunet, Joan Castellsagué, Joan Martrat, Griselda Urruticoechea, Ander Blanco, Ignacio Tihomirova, Laima Goldgar, David E. Buys, Saundra John, Esther M. Miron, Alexander Southey, Melissa Daly, Mary B. Schmutzler, Rita K. Wappenschmidt, Barbara Meindl, Alfons Arnold, Norbert Deissler, Helmut Varon-Mateeva, Raymonda Sutter, Christian Niederacher, Dieter Imyamitov, Evgeny Sinilnikova, Olga M. Stoppa-Lyonne, Dominique Mazoyer, Sylvie Verny-Pierre, Carole Castera, Laurent de Pauw, Antoine Bignon, Yves-Jean Uhrhammer, Nancy Peyrat, Jean-Philippe Vennin, Philippe Fert Ferrer, Sandra Collonge-Rame, Marie-Agnès Mortemousque, Isabelle Spurdle, Amanda B. Beesley, Jonathan Chen, Xiaoqing Healey, Sue Barcellos-Hoff, Mary Helen Vidal, Marc Gruber, Stephen B. Lázaro, Conxi Capellá, Gabriel McGuffog, Lesley Nathanson, Katherine L. Antoniou, Antonis C. Chenevix-Trench, Georgia Fleisch, Markus C. Moreno, Víctor Pujana, Miguel Angel |
author_facet | Maxwell, Christopher A. Benítez, Javier Gómez-Baldó, Laia Osorio, Ana Bonifaci, Núria Fernández-Ramires, Ricardo Costes, Sylvain V. Guinó, Elisabet Chen, Helen Evans, Gareth J. R. Mohan, Pooja Català, Isabel Petit, Anna Aguilar, Helena Villanueva, Alberto Aytes, Alvaro Serra-Musach, Jordi Rennert, Gad Lejbkowicz, Flavio Peterlongo, Paolo Manoukian, Siranoush Peissel, Bernard Ripamonti, Carla B. Bonanni, Bernardo Viel, Alessandra Allavena, Anna Bernard, Loris Radice, Paolo Friedman, Eitan Kaufman, Bella Laitman, Yael Dubrovsky, Maya Milgrom, Roni Jakubowska, Anna Cybulski, Cezary Gorski, Bohdan Jaworska, Katarzyna Durda, Katarzyna Sukiennicki, Grzegorz Lubiński, Jan Shugart, Yin Yao Domchek, Susan M. Letrero, Richard Weber, Barbara L. Hogervorst, Frans B. L. Rookus, Matti A. Collee, J. Margriet Devilee, Peter Ligtenberg, Marjolijn J. van der Luijt, Rob B. Aalfs, Cora M. Waisfisz, Quinten Wijnen, Juul van Roozendaal, Cornelis E. P. Easton, Douglas F. Peock, Susan Cook, Margaret Oliver, Clare Frost, Debra Harrington, Patricia Evans, D. Gareth Lalloo, Fiona Eeles, Rosalind Izatt, Louise Chu, Carol Eccles, Diana Douglas, Fiona Brewer, Carole Nevanlinna, Heli Heikkinen, Tuomas Couch, Fergus J. Lindor, Noralane M. Wang, Xianshu Godwin, Andrew K. Caligo, Maria A. Lombardi, Grazia Loman, Niklas Karlsson, Per Ehrencrona, Hans von Wachenfeldt, Anna Bjork Barkardottir, Rosa Hamann, Ute Rashid, Muhammad U. Lasa, Adriana Caldés, Trinidad Andrés, Raquel Schmitt, Michael Assmann, Volker Stevens, Kristen Offit, Kenneth Curado, João Tilgner, Hagen Guigó, Roderic Aiza, Gemma Brunet, Joan Castellsagué, Joan Martrat, Griselda Urruticoechea, Ander Blanco, Ignacio Tihomirova, Laima Goldgar, David E. Buys, Saundra John, Esther M. Miron, Alexander Southey, Melissa Daly, Mary B. Schmutzler, Rita K. Wappenschmidt, Barbara Meindl, Alfons Arnold, Norbert Deissler, Helmut Varon-Mateeva, Raymonda Sutter, Christian Niederacher, Dieter Imyamitov, Evgeny Sinilnikova, Olga M. Stoppa-Lyonne, Dominique Mazoyer, Sylvie Verny-Pierre, Carole Castera, Laurent de Pauw, Antoine Bignon, Yves-Jean Uhrhammer, Nancy Peyrat, Jean-Philippe Vennin, Philippe Fert Ferrer, Sandra Collonge-Rame, Marie-Agnès Mortemousque, Isabelle Spurdle, Amanda B. Beesley, Jonathan Chen, Xiaoqing Healey, Sue Barcellos-Hoff, Mary Helen Vidal, Marc Gruber, Stephen B. Lázaro, Conxi Capellá, Gabriel McGuffog, Lesley Nathanson, Katherine L. Antoniou, Antonis C. Chenevix-Trench, Georgia Fleisch, Markus C. Moreno, Víctor Pujana, Miguel Angel |
author_sort | Maxwell, Christopher A. |
collection | PubMed |
description | Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest that BRCA1 regulates stem/progenitor cell proliferation and differentiation. However, the function of BRCA1 in this process and its link to carcinogenesis remain unknown. Here we depict a molecular mechanism involving BRCA1 and RHAMM that regulates apicobasal polarity and, when perturbed, may increase risk of breast cancer. Starting from complementary genetic analyses across families and populations, we identified common genetic variation at the low-penetrance susceptibility HMMR locus (encoding for RHAMM) that modifies breast cancer risk among BRCA1, but probably not BRCA2, mutation carriers: n = 7,584, weighted hazard ratio ((w)HR) = 1.09 (95% CI 1.02–1.16), p(trend) = 0.017; and n = 3,965, (w)HR = 1.04 (95% CI 0.94–1.16), p(trend) = 0.43; respectively. Subsequently, studies of MCF10A apicobasal polarization revealed a central role for BRCA1 and RHAMM, together with AURKA and TPX2, in essential reorganization of microtubules. Mechanistically, reorganization is facilitated by BRCA1 and impaired by AURKA, which is regulated by negative feedback involving RHAMM and TPX2. Taken together, our data provide fundamental insight into apicobasal polarization through BRCA1 function, which may explain the expanded cell subsets and characteristic tumor type accompanying BRCA1 mutation, while also linking this process to sporadic breast cancer through perturbation of HMMR/RHAMM. |
format | Online Article Text |
id | pubmed-3217025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-32170252011-11-21 Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer Maxwell, Christopher A. Benítez, Javier Gómez-Baldó, Laia Osorio, Ana Bonifaci, Núria Fernández-Ramires, Ricardo Costes, Sylvain V. Guinó, Elisabet Chen, Helen Evans, Gareth J. R. Mohan, Pooja Català, Isabel Petit, Anna Aguilar, Helena Villanueva, Alberto Aytes, Alvaro Serra-Musach, Jordi Rennert, Gad Lejbkowicz, Flavio Peterlongo, Paolo Manoukian, Siranoush Peissel, Bernard Ripamonti, Carla B. Bonanni, Bernardo Viel, Alessandra Allavena, Anna Bernard, Loris Radice, Paolo Friedman, Eitan Kaufman, Bella Laitman, Yael Dubrovsky, Maya Milgrom, Roni Jakubowska, Anna Cybulski, Cezary Gorski, Bohdan Jaworska, Katarzyna Durda, Katarzyna Sukiennicki, Grzegorz Lubiński, Jan Shugart, Yin Yao Domchek, Susan M. Letrero, Richard Weber, Barbara L. Hogervorst, Frans B. L. Rookus, Matti A. Collee, J. Margriet Devilee, Peter Ligtenberg, Marjolijn J. van der Luijt, Rob B. Aalfs, Cora M. Waisfisz, Quinten Wijnen, Juul van Roozendaal, Cornelis E. P. Easton, Douglas F. Peock, Susan Cook, Margaret Oliver, Clare Frost, Debra Harrington, Patricia Evans, D. Gareth Lalloo, Fiona Eeles, Rosalind Izatt, Louise Chu, Carol Eccles, Diana Douglas, Fiona Brewer, Carole Nevanlinna, Heli Heikkinen, Tuomas Couch, Fergus J. Lindor, Noralane M. Wang, Xianshu Godwin, Andrew K. Caligo, Maria A. Lombardi, Grazia Loman, Niklas Karlsson, Per Ehrencrona, Hans von Wachenfeldt, Anna Bjork Barkardottir, Rosa Hamann, Ute Rashid, Muhammad U. Lasa, Adriana Caldés, Trinidad Andrés, Raquel Schmitt, Michael Assmann, Volker Stevens, Kristen Offit, Kenneth Curado, João Tilgner, Hagen Guigó, Roderic Aiza, Gemma Brunet, Joan Castellsagué, Joan Martrat, Griselda Urruticoechea, Ander Blanco, Ignacio Tihomirova, Laima Goldgar, David E. Buys, Saundra John, Esther M. Miron, Alexander Southey, Melissa Daly, Mary B. Schmutzler, Rita K. Wappenschmidt, Barbara Meindl, Alfons Arnold, Norbert Deissler, Helmut Varon-Mateeva, Raymonda Sutter, Christian Niederacher, Dieter Imyamitov, Evgeny Sinilnikova, Olga M. Stoppa-Lyonne, Dominique Mazoyer, Sylvie Verny-Pierre, Carole Castera, Laurent de Pauw, Antoine Bignon, Yves-Jean Uhrhammer, Nancy Peyrat, Jean-Philippe Vennin, Philippe Fert Ferrer, Sandra Collonge-Rame, Marie-Agnès Mortemousque, Isabelle Spurdle, Amanda B. Beesley, Jonathan Chen, Xiaoqing Healey, Sue Barcellos-Hoff, Mary Helen Vidal, Marc Gruber, Stephen B. Lázaro, Conxi Capellá, Gabriel McGuffog, Lesley Nathanson, Katherine L. Antoniou, Antonis C. Chenevix-Trench, Georgia Fleisch, Markus C. Moreno, Víctor Pujana, Miguel Angel PLoS Biol Research Article Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest that BRCA1 regulates stem/progenitor cell proliferation and differentiation. However, the function of BRCA1 in this process and its link to carcinogenesis remain unknown. Here we depict a molecular mechanism involving BRCA1 and RHAMM that regulates apicobasal polarity and, when perturbed, may increase risk of breast cancer. Starting from complementary genetic analyses across families and populations, we identified common genetic variation at the low-penetrance susceptibility HMMR locus (encoding for RHAMM) that modifies breast cancer risk among BRCA1, but probably not BRCA2, mutation carriers: n = 7,584, weighted hazard ratio ((w)HR) = 1.09 (95% CI 1.02–1.16), p(trend) = 0.017; and n = 3,965, (w)HR = 1.04 (95% CI 0.94–1.16), p(trend) = 0.43; respectively. Subsequently, studies of MCF10A apicobasal polarization revealed a central role for BRCA1 and RHAMM, together with AURKA and TPX2, in essential reorganization of microtubules. Mechanistically, reorganization is facilitated by BRCA1 and impaired by AURKA, which is regulated by negative feedback involving RHAMM and TPX2. Taken together, our data provide fundamental insight into apicobasal polarization through BRCA1 function, which may explain the expanded cell subsets and characteristic tumor type accompanying BRCA1 mutation, while also linking this process to sporadic breast cancer through perturbation of HMMR/RHAMM. Public Library of Science 2011-11-15 /pmc/articles/PMC3217025/ /pubmed/22110403 http://dx.doi.org/10.1371/journal.pbio.1001199 Text en Maxwell et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Maxwell, Christopher A. Benítez, Javier Gómez-Baldó, Laia Osorio, Ana Bonifaci, Núria Fernández-Ramires, Ricardo Costes, Sylvain V. Guinó, Elisabet Chen, Helen Evans, Gareth J. R. Mohan, Pooja Català, Isabel Petit, Anna Aguilar, Helena Villanueva, Alberto Aytes, Alvaro Serra-Musach, Jordi Rennert, Gad Lejbkowicz, Flavio Peterlongo, Paolo Manoukian, Siranoush Peissel, Bernard Ripamonti, Carla B. Bonanni, Bernardo Viel, Alessandra Allavena, Anna Bernard, Loris Radice, Paolo Friedman, Eitan Kaufman, Bella Laitman, Yael Dubrovsky, Maya Milgrom, Roni Jakubowska, Anna Cybulski, Cezary Gorski, Bohdan Jaworska, Katarzyna Durda, Katarzyna Sukiennicki, Grzegorz Lubiński, Jan Shugart, Yin Yao Domchek, Susan M. Letrero, Richard Weber, Barbara L. Hogervorst, Frans B. L. Rookus, Matti A. Collee, J. Margriet Devilee, Peter Ligtenberg, Marjolijn J. van der Luijt, Rob B. Aalfs, Cora M. Waisfisz, Quinten Wijnen, Juul van Roozendaal, Cornelis E. P. Easton, Douglas F. Peock, Susan Cook, Margaret Oliver, Clare Frost, Debra Harrington, Patricia Evans, D. Gareth Lalloo, Fiona Eeles, Rosalind Izatt, Louise Chu, Carol Eccles, Diana Douglas, Fiona Brewer, Carole Nevanlinna, Heli Heikkinen, Tuomas Couch, Fergus J. Lindor, Noralane M. Wang, Xianshu Godwin, Andrew K. Caligo, Maria A. Lombardi, Grazia Loman, Niklas Karlsson, Per Ehrencrona, Hans von Wachenfeldt, Anna Bjork Barkardottir, Rosa Hamann, Ute Rashid, Muhammad U. Lasa, Adriana Caldés, Trinidad Andrés, Raquel Schmitt, Michael Assmann, Volker Stevens, Kristen Offit, Kenneth Curado, João Tilgner, Hagen Guigó, Roderic Aiza, Gemma Brunet, Joan Castellsagué, Joan Martrat, Griselda Urruticoechea, Ander Blanco, Ignacio Tihomirova, Laima Goldgar, David E. Buys, Saundra John, Esther M. Miron, Alexander Southey, Melissa Daly, Mary B. Schmutzler, Rita K. Wappenschmidt, Barbara Meindl, Alfons Arnold, Norbert Deissler, Helmut Varon-Mateeva, Raymonda Sutter, Christian Niederacher, Dieter Imyamitov, Evgeny Sinilnikova, Olga M. Stoppa-Lyonne, Dominique Mazoyer, Sylvie Verny-Pierre, Carole Castera, Laurent de Pauw, Antoine Bignon, Yves-Jean Uhrhammer, Nancy Peyrat, Jean-Philippe Vennin, Philippe Fert Ferrer, Sandra Collonge-Rame, Marie-Agnès Mortemousque, Isabelle Spurdle, Amanda B. Beesley, Jonathan Chen, Xiaoqing Healey, Sue Barcellos-Hoff, Mary Helen Vidal, Marc Gruber, Stephen B. Lázaro, Conxi Capellá, Gabriel McGuffog, Lesley Nathanson, Katherine L. Antoniou, Antonis C. Chenevix-Trench, Georgia Fleisch, Markus C. Moreno, Víctor Pujana, Miguel Angel Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer |
title | Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer |
title_full | Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer |
title_fullStr | Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer |
title_full_unstemmed | Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer |
title_short | Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer |
title_sort | interplay between brca1 and rhamm regulates epithelial apicobasal polarization and may influence risk of breast cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217025/ https://www.ncbi.nlm.nih.gov/pubmed/22110403 http://dx.doi.org/10.1371/journal.pbio.1001199 |
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interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT vonwachenfeldtanna interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT bjorkbarkardottirrosa interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT hamannute interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT rashidmuhammadu interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT lasaadriana interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT caldestrinidad interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT andresraquel interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT schmittmichael interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT assmannvolker interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT stevenskristen interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT offitkenneth interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT curadojoao interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT tilgnerhagen interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT guigoroderic interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT aizagemma interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT brunetjoan interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT castellsaguejoan interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT martratgriselda interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT urruticoecheaander interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT blancoignacio interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT tihomirovalaima interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT goldgardavide interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT buyssaundra interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT johnestherm interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT mironalexander interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT southeymelissa interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT dalymaryb interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT schmutzlerritak interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT wappenschmidtbarbara interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT meindlalfons interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT arnoldnorbert interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT deisslerhelmut interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT varonmateevaraymonda interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT sutterchristian interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT niederacherdieter interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT imyamitovevgeny interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT sinilnikovaolgam interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT stoppalyonnedominique interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT mazoyersylvie interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT vernypierrecarole interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT casteralaurent interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT depauwantoine interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT bignonyvesjean interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT uhrhammernancy interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT peyratjeanphilippe interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT venninphilippe interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT fertferrersandra interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT collongeramemarieagnes interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT mortemousqueisabelle interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT spurdleamandab interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT beesleyjonathan interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT chenxiaoqing interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT healeysue interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT barcelloshoffmaryhelen interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT vidalmarc interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT gruberstephenb interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT lazaroconxi interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT capellagabriel interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT mcguffoglesley interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT nathansonkatherinel interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT antoniouantonisc interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT chenevixtrenchgeorgia interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT fleischmarkusc interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT morenovictor interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer AT pujanamiguelangel interplaybetweenbrca1andrhammregulatesepithelialapicobasalpolarizationandmayinfluenceriskofbreastcancer |