Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines

The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a s...

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Autores principales: Duque, María D., Camps, Pelayo, Profire, Lenuta, Montaner, Silvia, Vázquez, Santiago, Sureda, Francesc X., Mallol, Jordi, López-Querol, Marta, Naesens, Lieve, Clercq, Erik De, Radhika Prathalingam, S., Kelly, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. Published by Elsevier Ltd. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217223/
https://www.ncbi.nlm.nih.gov/pubmed/19251424
http://dx.doi.org/10.1016/j.bmc.2009.02.007
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author Duque, María D.
Camps, Pelayo
Profire, Lenuta
Montaner, Silvia
Vázquez, Santiago
Sureda, Francesc X.
Mallol, Jordi
López-Querol, Marta
Naesens, Lieve
Clercq, Erik De
Radhika Prathalingam, S.
Kelly, John M.
author_facet Duque, María D.
Camps, Pelayo
Profire, Lenuta
Montaner, Silvia
Vázquez, Santiago
Sureda, Francesc X.
Mallol, Jordi
López-Querol, Marta
Naesens, Lieve
Clercq, Erik De
Radhika Prathalingam, S.
Kelly, John M.
author_sort Duque, María D.
collection PubMed
description The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity.
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spelling pubmed-32172232011-11-16 Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines Duque, María D. Camps, Pelayo Profire, Lenuta Montaner, Silvia Vázquez, Santiago Sureda, Francesc X. Mallol, Jordi López-Querol, Marta Naesens, Lieve Clercq, Erik De Radhika Prathalingam, S. Kelly, John M. Bioorg Med Chem Article The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity. Elsevier Ltd. Published by Elsevier Ltd. 2009-04-15 2009-02-13 /pmc/articles/PMC3217223/ /pubmed/19251424 http://dx.doi.org/10.1016/j.bmc.2009.02.007 Text en Copyright © 2009 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Duque, María D.
Camps, Pelayo
Profire, Lenuta
Montaner, Silvia
Vázquez, Santiago
Sureda, Francesc X.
Mallol, Jordi
López-Querol, Marta
Naesens, Lieve
Clercq, Erik De
Radhika Prathalingam, S.
Kelly, John M.
Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
title Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
title_full Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
title_fullStr Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
title_full_unstemmed Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
title_short Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
title_sort synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217223/
https://www.ncbi.nlm.nih.gov/pubmed/19251424
http://dx.doi.org/10.1016/j.bmc.2009.02.007
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