Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines

The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a s...

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Detalles Bibliográficos
Autores principales: Duque, María D., Camps, Pelayo, Profire, Lenuta, Montaner, Silvia, Vázquez, Santiago, Sureda, Francesc X., Mallol, Jordi, López-Querol, Marta, Naesens, Lieve, Clercq, Erik De, Radhika Prathalingam, S., Kelly, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. Published by Elsevier Ltd. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217223/
https://www.ncbi.nlm.nih.gov/pubmed/19251424
http://dx.doi.org/10.1016/j.bmc.2009.02.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217223/
https://www.ncbi.nlm.nih.gov/pubmed/19251424
http://dx.doi.org/10.1016/j.bmc.2009.02.007

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