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Regulation of Neutrophil Survival/Apoptosis by Mcl-1
Neutrophil granulocytes have the shortest lifespan among leukocytes in the circulation and die via apoptosis. At sites of infection or tissue injury, prolongation of neutrophil lifespan is critical for effective host defense. Apoptosis of inflammatory neutrophils and their clearance are critical con...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
TheScientificWorldJOURNAL
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217587/ https://www.ncbi.nlm.nih.gov/pubmed/22125448 http://dx.doi.org/10.1100/2011/131539 |
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author | Milot, Eric Filep, János G. |
author_facet | Milot, Eric Filep, János G. |
author_sort | Milot, Eric |
collection | PubMed |
description | Neutrophil granulocytes have the shortest lifespan among leukocytes in the circulation and die via apoptosis. At sites of infection or tissue injury, prolongation of neutrophil lifespan is critical for effective host defense. Apoptosis of inflammatory neutrophils and their clearance are critical control points for termination of the inflammatory response. Evasion of neutrophil apoptosis aggravates local injury and leads to persistent tissue damage. The short-lived prosurvival Bcl-2 family protein, Mcl-1 (myeloid cell leukemia-1), is instrumental in controlling apoptosis and consequently neutrophil lifespan in response to rapidly changing environmental cues during inflammation. This paper will focus on multiple levels of control of Mcl-1 expression and function and will discuss targeting Mcl-1 as a potential therapeutic strategy to enhance the resolution of inflammation through accelerating neutrophil apoptosis. |
format | Online Article Text |
id | pubmed-3217587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | TheScientificWorldJOURNAL |
record_format | MEDLINE/PubMed |
spelling | pubmed-32175872011-11-28 Regulation of Neutrophil Survival/Apoptosis by Mcl-1 Milot, Eric Filep, János G. ScientificWorldJournal Review Article Neutrophil granulocytes have the shortest lifespan among leukocytes in the circulation and die via apoptosis. At sites of infection or tissue injury, prolongation of neutrophil lifespan is critical for effective host defense. Apoptosis of inflammatory neutrophils and their clearance are critical control points for termination of the inflammatory response. Evasion of neutrophil apoptosis aggravates local injury and leads to persistent tissue damage. The short-lived prosurvival Bcl-2 family protein, Mcl-1 (myeloid cell leukemia-1), is instrumental in controlling apoptosis and consequently neutrophil lifespan in response to rapidly changing environmental cues during inflammation. This paper will focus on multiple levels of control of Mcl-1 expression and function and will discuss targeting Mcl-1 as a potential therapeutic strategy to enhance the resolution of inflammation through accelerating neutrophil apoptosis. TheScientificWorldJOURNAL 2011-10-26 /pmc/articles/PMC3217587/ /pubmed/22125448 http://dx.doi.org/10.1100/2011/131539 Text en Copyright © 2011 E. Milot and J. G. Filep. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Milot, Eric Filep, János G. Regulation of Neutrophil Survival/Apoptosis by Mcl-1 |
title | Regulation of Neutrophil Survival/Apoptosis by Mcl-1 |
title_full | Regulation of Neutrophil Survival/Apoptosis by Mcl-1 |
title_fullStr | Regulation of Neutrophil Survival/Apoptosis by Mcl-1 |
title_full_unstemmed | Regulation of Neutrophil Survival/Apoptosis by Mcl-1 |
title_short | Regulation of Neutrophil Survival/Apoptosis by Mcl-1 |
title_sort | regulation of neutrophil survival/apoptosis by mcl-1 |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217587/ https://www.ncbi.nlm.nih.gov/pubmed/22125448 http://dx.doi.org/10.1100/2011/131539 |
work_keys_str_mv | AT miloteric regulationofneutrophilsurvivalapoptosisbymcl1 AT filepjanosg regulationofneutrophilsurvivalapoptosisbymcl1 |