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Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis

The effect of hyperbaric oxygen treatment (HBOT) was examined using MSG mice, which are an animal model of obesity, hyperlipidemia, diabetes, and nonalcoholic fatty liver disease. Nineteen MSG male mice were divided into HBOT treated and control groups at 12 weeks of ages. The HBOT group was treated...

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Autores principales: Tsuneyama, Koichi, Chen, Yen-Chen, Fujimoto, Makoto, Sasaki, Yoshiyuki, Suzuki, Wataru, Shimada, Tsutomu, Iizuka, Seiichi, Nagata, Mitsunobu, Aburada, Masaki, Chen, Shao-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217597/
https://www.ncbi.nlm.nih.gov/pubmed/22125461
http://dx.doi.org/10.1100/2011/380236
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author Tsuneyama, Koichi
Chen, Yen-Chen
Fujimoto, Makoto
Sasaki, Yoshiyuki
Suzuki, Wataru
Shimada, Tsutomu
Iizuka, Seiichi
Nagata, Mitsunobu
Aburada, Masaki
Chen, Shao-Yuan
author_facet Tsuneyama, Koichi
Chen, Yen-Chen
Fujimoto, Makoto
Sasaki, Yoshiyuki
Suzuki, Wataru
Shimada, Tsutomu
Iizuka, Seiichi
Nagata, Mitsunobu
Aburada, Masaki
Chen, Shao-Yuan
author_sort Tsuneyama, Koichi
collection PubMed
description The effect of hyperbaric oxygen treatment (HBOT) was examined using MSG mice, which are an animal model of obesity, hyperlipidemia, diabetes, and nonalcoholic fatty liver disease. Nineteen MSG male mice were divided into HBOT treated and control groups at 12 weeks of ages. The HBOT group was treated with hyperbaric oxygen from 12 to 14 weeks (first phase) and then from 16 to 18 weeks (second phase). Interestingly, the body weight of the HBOT group was significantly lower (P < 0.01) than that of the control group. In contrast, the serum lipid level did not show significant changes between the two groups. As for the effects of increasing oxidative stress, the liver histology of the HBOT group showed severer cellular damage and aberrant TNF-α expression. HBOT has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress.
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spelling pubmed-32175972011-11-28 Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis Tsuneyama, Koichi Chen, Yen-Chen Fujimoto, Makoto Sasaki, Yoshiyuki Suzuki, Wataru Shimada, Tsutomu Iizuka, Seiichi Nagata, Mitsunobu Aburada, Masaki Chen, Shao-Yuan ScientificWorldJournal Research Article The effect of hyperbaric oxygen treatment (HBOT) was examined using MSG mice, which are an animal model of obesity, hyperlipidemia, diabetes, and nonalcoholic fatty liver disease. Nineteen MSG male mice were divided into HBOT treated and control groups at 12 weeks of ages. The HBOT group was treated with hyperbaric oxygen from 12 to 14 weeks (first phase) and then from 16 to 18 weeks (second phase). Interestingly, the body weight of the HBOT group was significantly lower (P < 0.01) than that of the control group. In contrast, the serum lipid level did not show significant changes between the two groups. As for the effects of increasing oxidative stress, the liver histology of the HBOT group showed severer cellular damage and aberrant TNF-α expression. HBOT has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress. TheScientificWorldJOURNAL 2011-11-03 /pmc/articles/PMC3217597/ /pubmed/22125461 http://dx.doi.org/10.1100/2011/380236 Text en Copyright © 2011 Koichi Tsuneyama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tsuneyama, Koichi
Chen, Yen-Chen
Fujimoto, Makoto
Sasaki, Yoshiyuki
Suzuki, Wataru
Shimada, Tsutomu
Iizuka, Seiichi
Nagata, Mitsunobu
Aburada, Masaki
Chen, Shao-Yuan
Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis
title Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis
title_full Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis
title_fullStr Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis
title_full_unstemmed Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis
title_short Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis
title_sort advantages and disadvantages of hyperbaric oxygen treatment in mice with obesity hyperlipidemia and steatohepatitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217597/
https://www.ncbi.nlm.nih.gov/pubmed/22125461
http://dx.doi.org/10.1100/2011/380236
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