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The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis

The CD40 ligand (CD40L) and CD40 are two molecules belonging to the TNF/TNF receptor superfamily, and their role in adaptive immune system has widely been explored. However, the wide range of expression of these molecules on hematopoietic as well as nonhematopoietic cells has revealed multiple funct...

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Detalles Bibliográficos
Autores principales: Mavroudi, Irene, Papadaki, Helen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217605/
https://www.ncbi.nlm.nih.gov/pubmed/22125452
http://dx.doi.org/10.1100/2011/671453
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author Mavroudi, Irene
Papadaki, Helen A.
author_facet Mavroudi, Irene
Papadaki, Helen A.
author_sort Mavroudi, Irene
collection PubMed
description The CD40 ligand (CD40L) and CD40 are two molecules belonging to the TNF/TNF receptor superfamily, and their role in adaptive immune system has widely been explored. However, the wide range of expression of these molecules on hematopoietic as well as nonhematopoietic cells has revealed multiple functions of the CD40/CD40L interactions on different cell types and processes such as granulopoiesis. CD40 triggering on stromal cells has been documented to enhance the expression of granulopoiesis growth factors such as granulocyte-colony-stimulating factor (G-CSF) and granulocyte/monocyte-colony-stimulating factor (GM-CSF), and upon disruption of the CD40/CD40L-signaling pathway, as in the case of X-linked hyperimmunoglobulin M (IgM) syndrome (XHIGM), it can lead to neutropenia. In chronic idiopathic neutropenia (CIN) of adults, however, under the influence of an inflammatory microenvironment, CD40L plays a role in granulocytic progenitor cell depletion, providing thus a pathogenetic cause of CIN.
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spelling pubmed-32176052011-11-28 The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis Mavroudi, Irene Papadaki, Helen A. ScientificWorldJournal Review Article The CD40 ligand (CD40L) and CD40 are two molecules belonging to the TNF/TNF receptor superfamily, and their role in adaptive immune system has widely been explored. However, the wide range of expression of these molecules on hematopoietic as well as nonhematopoietic cells has revealed multiple functions of the CD40/CD40L interactions on different cell types and processes such as granulopoiesis. CD40 triggering on stromal cells has been documented to enhance the expression of granulopoiesis growth factors such as granulocyte-colony-stimulating factor (G-CSF) and granulocyte/monocyte-colony-stimulating factor (GM-CSF), and upon disruption of the CD40/CD40L-signaling pathway, as in the case of X-linked hyperimmunoglobulin M (IgM) syndrome (XHIGM), it can lead to neutropenia. In chronic idiopathic neutropenia (CIN) of adults, however, under the influence of an inflammatory microenvironment, CD40L plays a role in granulocytic progenitor cell depletion, providing thus a pathogenetic cause of CIN. Hindawi Publishing Corporation 2011-10-26 /pmc/articles/PMC3217605/ /pubmed/22125452 http://dx.doi.org/10.1100/2011/671453 Text en Copyright © 2011 I. Mavroudi and H. A. Papadaki. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mavroudi, Irene
Papadaki, Helen A.
The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis
title The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis
title_full The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis
title_fullStr The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis
title_full_unstemmed The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis
title_short The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis
title_sort role of cd40/cd40 ligand interactions in bone marrow granulopoiesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217605/
https://www.ncbi.nlm.nih.gov/pubmed/22125452
http://dx.doi.org/10.1100/2011/671453
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