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The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis
The CD40 ligand (CD40L) and CD40 are two molecules belonging to the TNF/TNF receptor superfamily, and their role in adaptive immune system has widely been explored. However, the wide range of expression of these molecules on hematopoietic as well as nonhematopoietic cells has revealed multiple funct...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217605/ https://www.ncbi.nlm.nih.gov/pubmed/22125452 http://dx.doi.org/10.1100/2011/671453 |
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author | Mavroudi, Irene Papadaki, Helen A. |
author_facet | Mavroudi, Irene Papadaki, Helen A. |
author_sort | Mavroudi, Irene |
collection | PubMed |
description | The CD40 ligand (CD40L) and CD40 are two molecules belonging to the TNF/TNF receptor superfamily, and their role in adaptive immune system has widely been explored. However, the wide range of expression of these molecules on hematopoietic as well as nonhematopoietic cells has revealed multiple functions of the CD40/CD40L interactions on different cell types and processes such as granulopoiesis. CD40 triggering on stromal cells has been documented to enhance the expression of granulopoiesis growth factors such as granulocyte-colony-stimulating factor (G-CSF) and granulocyte/monocyte-colony-stimulating factor (GM-CSF), and upon disruption of the CD40/CD40L-signaling pathway, as in the case of X-linked hyperimmunoglobulin M (IgM) syndrome (XHIGM), it can lead to neutropenia. In chronic idiopathic neutropenia (CIN) of adults, however, under the influence of an inflammatory microenvironment, CD40L plays a role in granulocytic progenitor cell depletion, providing thus a pathogenetic cause of CIN. |
format | Online Article Text |
id | pubmed-3217605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32176052011-11-28 The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis Mavroudi, Irene Papadaki, Helen A. ScientificWorldJournal Review Article The CD40 ligand (CD40L) and CD40 are two molecules belonging to the TNF/TNF receptor superfamily, and their role in adaptive immune system has widely been explored. However, the wide range of expression of these molecules on hematopoietic as well as nonhematopoietic cells has revealed multiple functions of the CD40/CD40L interactions on different cell types and processes such as granulopoiesis. CD40 triggering on stromal cells has been documented to enhance the expression of granulopoiesis growth factors such as granulocyte-colony-stimulating factor (G-CSF) and granulocyte/monocyte-colony-stimulating factor (GM-CSF), and upon disruption of the CD40/CD40L-signaling pathway, as in the case of X-linked hyperimmunoglobulin M (IgM) syndrome (XHIGM), it can lead to neutropenia. In chronic idiopathic neutropenia (CIN) of adults, however, under the influence of an inflammatory microenvironment, CD40L plays a role in granulocytic progenitor cell depletion, providing thus a pathogenetic cause of CIN. Hindawi Publishing Corporation 2011-10-26 /pmc/articles/PMC3217605/ /pubmed/22125452 http://dx.doi.org/10.1100/2011/671453 Text en Copyright © 2011 I. Mavroudi and H. A. Papadaki. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Mavroudi, Irene Papadaki, Helen A. The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis |
title | The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis |
title_full | The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis |
title_fullStr | The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis |
title_full_unstemmed | The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis |
title_short | The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis |
title_sort | role of cd40/cd40 ligand interactions in bone marrow granulopoiesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217605/ https://www.ncbi.nlm.nih.gov/pubmed/22125452 http://dx.doi.org/10.1100/2011/671453 |
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