Synthesis of novel 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines and their antihyperglycemic activity

A number of 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines 6a-f derivatives were synthesized and their antihyperglycemic activity was evaluated by streptozotocin (STZ) and sucrose-loaded model. Many of oxazolidine derivatives as well as their corresponding substituted phenyl...

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Autor principal: Panneerselvam, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications Pvt Ltd 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217684/
https://www.ncbi.nlm.nih.gov/pubmed/22171291
http://dx.doi.org/10.4103/2231-4040.79804
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author Panneerselvam, T.
author_facet Panneerselvam, T.
author_sort Panneerselvam, T.
collection PubMed
description A number of 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines 6a-f derivatives were synthesized and their antihyperglycemic activity was evaluated by streptozotocin (STZ) and sucrose-loaded model. Many of oxazolidine derivatives as well as their corresponding substituted phenylhydrazine showed significant reduction in blood glucose level in STZ and sucrose-loaded rat models.
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spelling pubmed-32176842011-12-14 Synthesis of novel 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines and their antihyperglycemic activity Panneerselvam, T. J Adv Pharm Technol Res Original Article A number of 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines 6a-f derivatives were synthesized and their antihyperglycemic activity was evaluated by streptozotocin (STZ) and sucrose-loaded model. Many of oxazolidine derivatives as well as their corresponding substituted phenylhydrazine showed significant reduction in blood glucose level in STZ and sucrose-loaded rat models. Medknow Publications Pvt Ltd 2011 /pmc/articles/PMC3217684/ /pubmed/22171291 http://dx.doi.org/10.4103/2231-4040.79804 Text en © Journal of Advanced Pharmaceutical Technology & Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Panneerselvam, T.
Synthesis of novel 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines and their antihyperglycemic activity
title Synthesis of novel 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines and their antihyperglycemic activity
title_full Synthesis of novel 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines and their antihyperglycemic activity
title_fullStr Synthesis of novel 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines and their antihyperglycemic activity
title_full_unstemmed Synthesis of novel 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines and their antihyperglycemic activity
title_short Synthesis of novel 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines and their antihyperglycemic activity
title_sort synthesis of novel 3-benzyl-2-phenyl-4(5h)-(substituted phenylhydrazino)-1, 3-oxazolidines and their antihyperglycemic activity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217684/
https://www.ncbi.nlm.nih.gov/pubmed/22171291
http://dx.doi.org/10.4103/2231-4040.79804
work_keys_str_mv AT panneerselvamt synthesisofnovel3benzyl2phenyl45hsubstitutedphenylhydrazino13oxazolidinesandtheirantihyperglycemicactivity

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