LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury

BACKGROUND: Toll-like receptor 4 (TLR4) is activated in response to cerebral ischemia leading to substantial brain damage. In contrast, mild activation of TLR4 by preconditioning with low dose exposure to lipopolysaccharide (LPS) prior to cerebral ischemia dramatically improves outcome by reprogramm...

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Detalles Bibliográficos
Autores principales: Vartanian, Keri B, Stevens, Susan L, Marsh, Brenda J, Williams-Karnesky, Rebecca, Lessov, Nikola S, Stenzel-Poore, Mary P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217906/
https://www.ncbi.nlm.nih.gov/pubmed/21999375
http://dx.doi.org/10.1186/1742-2094-8-140

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