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Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1?
PURPOSE: Many kinds of substances are produced on vascular endothelial activation. The aim of this study is to confirm an increase in Endothelin-1 (ET-1), the most potent vasoconstrictor, which is produced by endothelial activation, in patients with chronic anal fissure and to infer the relationship...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Coloproctology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218127/ https://www.ncbi.nlm.nih.gov/pubmed/22102973 http://dx.doi.org/10.3393/jksc.2011.27.5.237 |
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author | Lim, Cheong Ho Shin, Hyeon Keun Kang, Wook Ho Jeong, Seung Kyu Yang, Hyung Kyu |
author_facet | Lim, Cheong Ho Shin, Hyeon Keun Kang, Wook Ho Jeong, Seung Kyu Yang, Hyung Kyu |
author_sort | Lim, Cheong Ho |
collection | PubMed |
description | PURPOSE: Many kinds of substances are produced on vascular endothelial activation. The aim of this study is to confirm an increase in Endothelin-1 (ET-1), the most potent vasoconstrictor, which is produced by endothelial activation, in patients with chronic anal fissure and to infer the relationship between ET-1 and anal fissure chronicity. METHODS: The study groups are divided into three different groups with 30 subjects each. Group 1 is comprised of healthy volunteers, group 2 of chronic anal fissure patients, and Group 3 of patients with higher than 3rd degree hemorrhoids. Blood samples were taken to measure the ET-1 levels in subject's serum and to compare the results with those for the control groups. RESULTS: Among the 90 subjects, 38 were male, and 52 were female. The average age was 36.8. The average ET-1 level marked 1.47 ± 0.78 pg/mL for male subjects and 1.16 ± 0.47 pg/mL for female subjects (P = 0.02). The average ET-1 level in the patient groups is as follow: 1.21 ± 0.44 pg/mL in group 1, 1.46 ± 0.83 pg/mL in group 2, and 1.20 ± 0.56 pg/mL in group 3 (P = 0.14). CONCLUSION: Group 2, the chronic anal fissure patient group, showed a higher ET-1 level than groups 1 and 3, the control group and the hemorrhoid patient group, but this difference had no statistical significance. |
format | Online Article Text |
id | pubmed-3218127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Korean Society of Coloproctology |
record_format | MEDLINE/PubMed |
spelling | pubmed-32181272011-11-18 Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1? Lim, Cheong Ho Shin, Hyeon Keun Kang, Wook Ho Jeong, Seung Kyu Yang, Hyung Kyu J Korean Soc Coloproctol Original Article PURPOSE: Many kinds of substances are produced on vascular endothelial activation. The aim of this study is to confirm an increase in Endothelin-1 (ET-1), the most potent vasoconstrictor, which is produced by endothelial activation, in patients with chronic anal fissure and to infer the relationship between ET-1 and anal fissure chronicity. METHODS: The study groups are divided into three different groups with 30 subjects each. Group 1 is comprised of healthy volunteers, group 2 of chronic anal fissure patients, and Group 3 of patients with higher than 3rd degree hemorrhoids. Blood samples were taken to measure the ET-1 levels in subject's serum and to compare the results with those for the control groups. RESULTS: Among the 90 subjects, 38 were male, and 52 were female. The average age was 36.8. The average ET-1 level marked 1.47 ± 0.78 pg/mL for male subjects and 1.16 ± 0.47 pg/mL for female subjects (P = 0.02). The average ET-1 level in the patient groups is as follow: 1.21 ± 0.44 pg/mL in group 1, 1.46 ± 0.83 pg/mL in group 2, and 1.20 ± 0.56 pg/mL in group 3 (P = 0.14). CONCLUSION: Group 2, the chronic anal fissure patient group, showed a higher ET-1 level than groups 1 and 3, the control group and the hemorrhoid patient group, but this difference had no statistical significance. The Korean Society of Coloproctology 2011-10 2011-10-31 /pmc/articles/PMC3218127/ /pubmed/22102973 http://dx.doi.org/10.3393/jksc.2011.27.5.237 Text en © 2011 The Korean Society of Coloproctology http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lim, Cheong Ho Shin, Hyeon Keun Kang, Wook Ho Jeong, Seung Kyu Yang, Hyung Kyu Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1? |
title | Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1? |
title_full | Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1? |
title_fullStr | Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1? |
title_full_unstemmed | Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1? |
title_short | Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1? |
title_sort | is there any relationship between the chronicity of chronic anal fissure and endothelin-1? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218127/ https://www.ncbi.nlm.nih.gov/pubmed/22102973 http://dx.doi.org/10.3393/jksc.2011.27.5.237 |
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