Oxaliplatin-induced Pulmonary Fibrosis: Two Case Reports

Oxaliplatin with infusional 5-fluorouracil plus leucovorin (FOLFOX regimen) is the one of the standard chemotherapy regimens for treating a colorectal carcinoma. The most common side effects include neutropenia, diarrhea, vomiting and peripheral neuropathy, and these are moderate and manageable. How...

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Detalles Bibliográficos
Autores principales: Ryu, Chun-Geun, Jung, Eun-Joo, Kim, Gangmi, Kim, Su Ran, Hwang, Dae-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Coloproctology 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218132/
https://www.ncbi.nlm.nih.gov/pubmed/22102978
http://dx.doi.org/10.3393/jksc.2011.27.5.266
Descripción
Sumario:Oxaliplatin with infusional 5-fluorouracil plus leucovorin (FOLFOX regimen) is the one of the standard chemotherapy regimens for treating a colorectal carcinoma. The most common side effects include neutropenia, diarrhea, vomiting and peripheral neuropathy, and these are moderate and manageable. However, pulmonary toxicity is rarely reported to be associated with the FOLFOX regimen. Moreover, there is no established guideline for the management of this side effect. Here, along with a literature review, we report two cases of rapidly developing pulmonary fibrosis related to the use of the FOLFOX regimen in patients with colorectal carcinomas.

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