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Selection of an improved HDAC8 inhibitor through structure-based drug design

Histone deacetylases (HDACs) are enzymes, which catalyze the removal of acetyl moiety from acetyl-lysine within the histone proteins and promote gene repression and silencing resulting in several types of cancer. HDACs are important therapeutic targets for the treatment of cancer and related disease...

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Detalles Bibliográficos
Autores principales:	Vijayakumar, Balakrishnan, Umamaheswari, Appavoo, Puratchikody, Ayarivan, Velmurugan, Devadasan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Biomedical Informatics 2011
Materias:	Hypothesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218316/ https://www.ncbi.nlm.nih.gov/pubmed/22125384

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