A polymeric colchicinoid prodrug with reduced toxicity and improved efficacy for vascular disruption in cancer therapy

Colchicinoids are very potent tubulin-binding compounds, which interfere with microtubule formation, giving them strong cytotoxic properties, such as cell mitosis inhibition and induction of microcytoskeleton depolymerization. While this makes them promising vascular disrupting agents (VDAs) in canc...

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Detalles Bibliográficos
Autores principales: Crielaard, Bart J, van der Wal, Steffen, Lammers, Twan, Le, Huong Thu, Hennink, Wim E, Schiffelers, Raymond M, Storm, Gert, Fens, Marcel HAM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218583/
https://www.ncbi.nlm.nih.gov/pubmed/22114500
http://dx.doi.org/10.2147/IJN.S24450

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