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Current perspectives on the role of IL-17 in autoimmune disease

Until recently, autoimmune diseases had been categorized as either Th1- or Th2-mediated diseases. However, the discovery of a novel subset of helper T cells producing interleukin (IL)-17, ie, Th17 cells, changed this paradigm. Currently, IL-17 and Th17 cells are implicated in many autoimmune disease...

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Autor principal: Yamada, Hisakata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218730/
https://www.ncbi.nlm.nih.gov/pubmed/22096355
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author Yamada, Hisakata
author_facet Yamada, Hisakata
author_sort Yamada, Hisakata
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description Until recently, autoimmune diseases had been categorized as either Th1- or Th2-mediated diseases. However, the discovery of a novel subset of helper T cells producing interleukin (IL)-17, ie, Th17 cells, changed this paradigm. Currently, IL-17 and Th17 cells are implicated in many autoimmune diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel diseases. Such conclusions were initially drawn from observations in animal models of autoimmune diseases, and accumulating data from clinical research also support the involvement of IL-17 in human diseases as well. Reagents targeting Th17-related molecules have been under clinical investigation for some diseases but have not always been effective in controlling disease activity. Consistent with this, it has become evident that there are substantial differences in the development of Th17 cells and in the way they function in autoimmune diseases between humans and experimental animals. Thus, further investigation is needed before we can draw any conclusions about the importance of IL-17 and Th17 cells in human autoimmune diseases.
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spelling pubmed-32187302011-11-17 Current perspectives on the role of IL-17 in autoimmune disease Yamada, Hisakata J Inflamm Res Review Until recently, autoimmune diseases had been categorized as either Th1- or Th2-mediated diseases. However, the discovery of a novel subset of helper T cells producing interleukin (IL)-17, ie, Th17 cells, changed this paradigm. Currently, IL-17 and Th17 cells are implicated in many autoimmune diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel diseases. Such conclusions were initially drawn from observations in animal models of autoimmune diseases, and accumulating data from clinical research also support the involvement of IL-17 in human diseases as well. Reagents targeting Th17-related molecules have been under clinical investigation for some diseases but have not always been effective in controlling disease activity. Consistent with this, it has become evident that there are substantial differences in the development of Th17 cells and in the way they function in autoimmune diseases between humans and experimental animals. Thus, further investigation is needed before we can draw any conclusions about the importance of IL-17 and Th17 cells in human autoimmune diseases. Dove Medical Press 2010-06-18 /pmc/articles/PMC3218730/ /pubmed/22096355 Text en © 2010 Yamada, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Yamada, Hisakata
Current perspectives on the role of IL-17 in autoimmune disease
title Current perspectives on the role of IL-17 in autoimmune disease
title_full Current perspectives on the role of IL-17 in autoimmune disease
title_fullStr Current perspectives on the role of IL-17 in autoimmune disease
title_full_unstemmed Current perspectives on the role of IL-17 in autoimmune disease
title_short Current perspectives on the role of IL-17 in autoimmune disease
title_sort current perspectives on the role of il-17 in autoimmune disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218730/
https://www.ncbi.nlm.nih.gov/pubmed/22096355
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