Targeted enrichment beyond the consensus coding DNA sequence exome reveals exons with higher variant densities

BACKGROUND: Enrichment of loci by DNA hybridization-capture, followed by high-throughput sequencing, is an important tool in modern genetics. Currently, the most common targets for enrichment are the protein coding exons represented by the consensus coding DNA sequence (CCDS). The CCDS, however, exc...

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Detalles Bibliográficos
Autores principales: Bainbridge, Matthew N, Wang, Min, Wu, Yuanqing, Newsham, Irene, Muzny, Donna M, Jefferies, John L, Albert, Thomas J, Burgess, Daniel L, Gibbs, Richard A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218830/
https://www.ncbi.nlm.nih.gov/pubmed/21787409
http://dx.doi.org/10.1186/gb-2011-12-7-r68

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