What does biologically meaningful mean? A perspective on gene regulatory network validation

Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.

Detalles Bibliográficos
Autor principal: Walhout, Albertha JM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218850/
https://www.ncbi.nlm.nih.gov/pubmed/21489330
http://dx.doi.org/10.1186/gb-2011-12-4-109
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author Walhout, Albertha JM
author_facet Walhout, Albertha JM
author_sort Walhout, Albertha JM
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description Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.
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spelling pubmed-32188502012-04-11 What does biologically meaningful mean? A perspective on gene regulatory network validation Walhout, Albertha JM Genome Biol Opinion Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously. BioMed Central 2011 2011-04-11 /pmc/articles/PMC3218850/ /pubmed/21489330 http://dx.doi.org/10.1186/gb-2011-12-4-109 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Opinion
Walhout, Albertha JM
What does biologically meaningful mean? A perspective on gene regulatory network validation
title What does biologically meaningful mean? A perspective on gene regulatory network validation
title_full What does biologically meaningful mean? A perspective on gene regulatory network validation
title_fullStr What does biologically meaningful mean? A perspective on gene regulatory network validation
title_full_unstemmed What does biologically meaningful mean? A perspective on gene regulatory network validation
title_short What does biologically meaningful mean? A perspective on gene regulatory network validation
title_sort what does biologically meaningful mean? a perspective on gene regulatory network validation
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218850/
https://www.ncbi.nlm.nih.gov/pubmed/21489330
http://dx.doi.org/10.1186/gb-2011-12-4-109
work_keys_str_mv AT walhoutalberthajm whatdoesbiologicallymeaningfulmeanaperspectiveongeneregulatorynetworkvalidation

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