Cargando…

High recombination rates and hotspots in a Plasmodium falciparum genetic cross

BACKGROUND: The human malaria parasite Plasmodium falciparum survives pressures from the host immune system and antimalarial drugs by modifying its genome. Genetic recombination and nucleotide substitution are the two major mechanisms that the parasite employs to generate genome diversity. A better...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Hongying, Li, Na, Gopalan, Vivek, Zilversmit, Martine M, Varma, Sudhir, Nagarajan, Vijayaraj, Li, Jian, Mu, Jianbing, Hayton, Karen, Henschen, Bruce, Yi, Ming, Stephens, Robert, McVean, Gilean, Awadalla, Philip, Wellems, Thomas E, Su, Xin-zhuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218859/ https://www.ncbi.nlm.nih.gov/pubmed/21463505 http://dx.doi.org/10.1186/gb-2011-12-4-r33

Ejemplares similares

Recombination Hotspots and Population Structure in Plasmodium falciparum
por: Mu, Jianbing, et al.
Publicado: (2005)

Population Genomics of the Immune Evasion (var) Genes of Plasmodium falciparum
por: Barry, Alyssa E, et al.
Publicado: (2007)

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum
por: Yuan, Jing, et al.
Publicado: (2009)

Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum
por: Miles, Alistair, et al.
Publicado: (2016)

Hypervariable antigen genes in malaria have ancient roots
por: Zilversmit, Martine M, et al.
Publicado: (2013)

Trinculo: Bayesian and frequentist multinomial logistic regression for genome-wide association studies of multi-category phenotypes
por: Jostins, Luke, et al.
Publicado: (2016)

Deconvolution of multiple infections in Plasmodium falciparum from high throughput sequencing data
por: Zhu, Sha Joe, et al.
Publicado: (2018)

Graphical Model Selection for Gaussian Conditional Random Fields in the Presence of Latent Variables
por: Frot, Benjamin, et al.
Publicado: (2018)

Efficient Coalescent Simulation and Genealogical Analysis for Large Sample Sizes
por: Kelleher, Jerome, et al.
Publicado: (2016)

Genome-Wide Compensatory Changes Accompany Drug- Selected Mutations in the Plasmodium falciparum crt Gene
por: Jiang, Hongying, et al.
Publicado: (2008)

Detection of genome-wide polymorphisms in the AT-rich Plasmodium falciparum genome using a high-density microarray
por: Jiang, Hongying, et al.
Publicado: (2008)

Recent Progress in Functional Genomic Research in Plasmodium falciparum
por: Mu, Jianbing, et al.
Publicado: (2010)

cDNA sequences reveal considerable gene prediction inaccuracy in the Plasmodium falciparum genome
por: Lu, Fangli, et al.
Publicado: (2007)

Correction: Population Genomics of the Immune Evasion (var) Genes of Plasmodium falciparum
por: Barry, Alyssa E, et al.
Publicado: (2007)

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs
por: Mu, Jianbing, et al.
Publicado: (2010)

A set of microsatellite markers to differentiate Plasmodium falciparum progeny of four genetic crosses
por: Figan, Christine E., et al.
Publicado: (2018)

A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence
por: Nair, Sethu C., et al.
Publicado: (2017)

Elucidating relationships between P.falciparum prevalence and measures of genetic diversity with a combined genetic-epidemiological model of malaria
por: Hendry, Jason A., et al.
Publicado: (2021)

Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione
por: Raj, Dipak Kumar, et al.
Publicado: (2009)

Epidemiology of subpatent Plasmodium falciparum infection: implications for detection of hotspots with imperfect diagnostics
por: Mosha, Jacklin F, et al.
Publicado: (2013)

Evidence for linkage of pfmdr1, pfcrt, and pfk13 polymorphisms to lumefantrine and mefloquine susceptibilities in a Plasmodium falciparum cross
por: Windle, Sean T., et al.
Publicado: (2020)

Sensitive Immunoassay Detection of Plasmodium Lactate Dehydrogenase by Inductively Coupled Plasma Mass Spectrometry
por: Mu, Jianbing, et al.
Publicado: (2021)

Polyunsaturated fatty acids promote Plasmodium falciparum gametocytogenesis
por: Tanaka, Takeshi Q., et al.
Publicado: (2019)

Functional Characterization of the Plasmodium falciparum Chloroquine-Resistance Transporter (PfCRT) in Transformed Dictyostelium discoideum Vesicles
por: Papakrivos, Janni, et al.
Publicado: (2012)

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
por: Miotto, Olivo, et al.
Publicado: (2013)

A high-throughput method to detect Plasmodium falciparum clones in limiting dilution microplates
por: Lyko, Brian, et al.
Publicado: (2012)

Prevalence of Plasmodium falciparum anti-malarial resistance-associated polymorphisms in pfcrt, pfmdr1 and pfnhe1 in Muheza, Tanzania, prior to introduction of artemisinin combination therapy
por: Gadalla, Nahla B, et al.
Publicado: (2015)

Profiling invasive Plasmodium falciparum merozoites using an integrated omics approach
por: Kumar, Krishan, et al.
Publicado: (2017)

Tetracysteine-Based Fluorescent Tags to Study Protein Localization and Trafficking in Plasmodium falciparum-Infected Erythrocytes
por: Crivat, Georgeta, et al.
Publicado: (2011)

Plasmodium genetic loci linked to host cytokine and chemokine responses
por: Pattaradilokrat, Sittiporn, et al.
Publicado: (2014)

A Genealogical Interpretation of Principal Components Analysis
por: McVean, Gil
Publicado: (2009)

Low-Bias RNA Sequencing of the HIV-2 Genome from Blood Plasma
por: James, Katherine L., et al.
Publicado: (2018)

A Multidomain Adhesion Protein Family Expressed in Plasmodium falciparum Is Essential for Transmission to the Mosquito
por: Pradel, Gabriele, et al.
Publicado: (2004)

Computational Clues of Immunogenic Hotspots in Plasmodium falciparum Erythrocytic Stage Vaccine Candidate Antigens: In Silico Approach
por: Azimi-Resketi, Mojtaba, et al.
Publicado: (2022)

Alternative methods for the Plasmodium falciparum artemisinin ring-stage survival assay with increased simplicity and parasite stage-specificity
por: Kite, Whitney A., et al.
Publicado: (2016)

Differential confounding of rare and common variants in spatially structured populations
por: Mathieson, Iain, et al.
Publicado: (2012)

Demography and the Age of Rare Variants
por: Mathieson, Iain, et al.
Publicado: (2014)

Estimating Selection Coefficients in Spatially Structured Populations from Time Series Data of Allele Frequencies
por: Mathieson, Iain, et al.
Publicado: (2013)

Valproic Acid as a Potential Inhibitor of Plasmodium falciparum Histone Deacetylase 1 (PfHDAC1): An in Silico Approach
por: Elbadawi, Mohamed A. Abdallah, et al.
Publicado: (2015)

Restructured Mitochondrial-Nuclear Interaction in Plasmodium falciparum Dormancy and Persister Survival after Artemisinin Exposure
por: Connelly, Sean V., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_plvtjpoqe1e1cehnqg5pl8uk82