Cargando…
Liver involvement in subjects with rheumatic disease
The liver is often overlooked as a target organ, with pathology either secondary to an underlying disease or due to the toxicity of therapies and the medical complications of extrahepatic diseases. It is thus important for the clinical rheumatologist to be aware of the diagnostic procedure to monito...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218873/ https://www.ncbi.nlm.nih.gov/pubmed/21722332 http://dx.doi.org/10.1186/ar3319 |
_version_ | 1782216747081793536 |
---|---|
author | Selmi, Carlo De Santis, Maria Gershwin, M Eric |
author_facet | Selmi, Carlo De Santis, Maria Gershwin, M Eric |
author_sort | Selmi, Carlo |
collection | PubMed |
description | The liver is often overlooked as a target organ, with pathology either secondary to an underlying disease or due to the toxicity of therapies and the medical complications of extrahepatic diseases. It is thus important for the clinical rheumatologist to be aware of the diagnostic procedure to monitor liver injury. Indeed, systemic rheumatologic diseases may be associated with liver abnormalities secondary to the presence of a coexisting autoimmune liver disease (particularly primary biliary cirrhosis or autoimmune hepatitis), the direct involvement of the liver parenchyma, or the impact of medical treatments (particularly methotrexate) on the liver. In addition, the rheumatologist should be aware of the impact of immunosuppressive agents on underlying viral infections, particularly viral hepatitis. We review herein the data on the role of the liver in the clinical management of systemic rheumatic diseases. |
format | Online Article Text |
id | pubmed-3218873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32188732011-12-30 Liver involvement in subjects with rheumatic disease Selmi, Carlo De Santis, Maria Gershwin, M Eric Arthritis Res Ther Review The liver is often overlooked as a target organ, with pathology either secondary to an underlying disease or due to the toxicity of therapies and the medical complications of extrahepatic diseases. It is thus important for the clinical rheumatologist to be aware of the diagnostic procedure to monitor liver injury. Indeed, systemic rheumatologic diseases may be associated with liver abnormalities secondary to the presence of a coexisting autoimmune liver disease (particularly primary biliary cirrhosis or autoimmune hepatitis), the direct involvement of the liver parenchyma, or the impact of medical treatments (particularly methotrexate) on the liver. In addition, the rheumatologist should be aware of the impact of immunosuppressive agents on underlying viral infections, particularly viral hepatitis. We review herein the data on the role of the liver in the clinical management of systemic rheumatic diseases. BioMed Central 2011 2011-06-30 /pmc/articles/PMC3218873/ /pubmed/21722332 http://dx.doi.org/10.1186/ar3319 Text en Copyright ©2011 BioMed Central Ltd |
spellingShingle | Review Selmi, Carlo De Santis, Maria Gershwin, M Eric Liver involvement in subjects with rheumatic disease |
title | Liver involvement in subjects with rheumatic disease |
title_full | Liver involvement in subjects with rheumatic disease |
title_fullStr | Liver involvement in subjects with rheumatic disease |
title_full_unstemmed | Liver involvement in subjects with rheumatic disease |
title_short | Liver involvement in subjects with rheumatic disease |
title_sort | liver involvement in subjects with rheumatic disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218873/ https://www.ncbi.nlm.nih.gov/pubmed/21722332 http://dx.doi.org/10.1186/ar3319 |
work_keys_str_mv | AT selmicarlo liverinvolvementinsubjectswithrheumaticdisease AT desantismaria liverinvolvementinsubjectswithrheumaticdisease AT gershwinmeric liverinvolvementinsubjectswithrheumaticdisease |