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The new era of autoimmune disease research
Recent genome-wide association studies have advanced our understanding of genetic factors that underlie systemic lupus erythematosus (SLE), a multifactorial autoimmune disease characterized by various clinical manifestations. SLE also has an environmental component, which can trigger or exacerbate t...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218883/ https://www.ncbi.nlm.nih.gov/pubmed/21639950 http://dx.doi.org/10.1186/ar3335 |
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author | Koike, Takao |
author_facet | Koike, Takao |
author_sort | Koike, Takao |
collection | PubMed |
description | Recent genome-wide association studies have advanced our understanding of genetic factors that underlie systemic lupus erythematosus (SLE), a multifactorial autoimmune disease characterized by various clinical manifestations. SLE also has an environmental component, which can trigger or exacerbate the disease. Despite extensive efforts aimed at elucidating the cellular and biological abnormalities that arise in the immune system of patients with SLE, its pathology remains unclear. Lee and colleagues recently carried out gene expression profiling of patients with SLE followed by bioinformatics analysis and discovered the existence of abnormal regulatory networks and potential key molecules. The authors found that ATP synthesis and DNA repair pathways may be involved in the pathogenesis, providing a potential explanation for photosensitivity experienced by patients with SLE. |
format | Online Article Text |
id | pubmed-3218883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32188832011-12-01 The new era of autoimmune disease research Koike, Takao Arthritis Res Ther Editorial Recent genome-wide association studies have advanced our understanding of genetic factors that underlie systemic lupus erythematosus (SLE), a multifactorial autoimmune disease characterized by various clinical manifestations. SLE also has an environmental component, which can trigger or exacerbate the disease. Despite extensive efforts aimed at elucidating the cellular and biological abnormalities that arise in the immune system of patients with SLE, its pathology remains unclear. Lee and colleagues recently carried out gene expression profiling of patients with SLE followed by bioinformatics analysis and discovered the existence of abnormal regulatory networks and potential key molecules. The authors found that ATP synthesis and DNA repair pathways may be involved in the pathogenesis, providing a potential explanation for photosensitivity experienced by patients with SLE. BioMed Central 2011 2011-05-31 /pmc/articles/PMC3218883/ /pubmed/21639950 http://dx.doi.org/10.1186/ar3335 Text en Copyright ©2011 BioMed Central Ltd |
spellingShingle | Editorial Koike, Takao The new era of autoimmune disease research |
title | The new era of autoimmune disease research |
title_full | The new era of autoimmune disease research |
title_fullStr | The new era of autoimmune disease research |
title_full_unstemmed | The new era of autoimmune disease research |
title_short | The new era of autoimmune disease research |
title_sort | new era of autoimmune disease research |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218883/ https://www.ncbi.nlm.nih.gov/pubmed/21639950 http://dx.doi.org/10.1186/ar3335 |
work_keys_str_mv | AT koiketakao theneweraofautoimmunediseaseresearch AT koiketakao neweraofautoimmunediseaseresearch |