Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis

INTRODUCTION: Endothelin-1, a vasoconstrictor peptide, influences cartilage metabolism mainly via endothelin receptor type A (ETA). Along with the inflammatory nonapeptide vasodilator bradykinin (BK), which acts via bradykinin receptor B1 (BKB1) in chronic inflammatory conditions, these vasoactive f...

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Detalles Bibliográficos
Autores principales: Kaufman, Gabriel N, Zaouter, Charlotte, Valteau, Barthélémy, Sirois, Pierre, Moldovan, Florina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218886/
https://www.ncbi.nlm.nih.gov/pubmed/21575197
http://dx.doi.org/10.1186/ar3338

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