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Who is in the driver's seat in 8p12 amplifications? ZNF703 in luminal B breast tumors

Two recent reports identify ZNF703 as an oncogene driving selection of frequent chromosome 8p12 amplifications in luminal B breast tumors. The estrogen-responsive ZNF703 gene encodes a transcriptional cofactor that, when overexpressed, induces cell proliferation and interferes with transforming grow...

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Detalles Bibliográficos
Autores principales:	Bazarov, Alexey V, Yaswen, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Viewpoint
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218931/ https://www.ncbi.nlm.nih.gov/pubmed/21635707 http://dx.doi.org/10.1186/bcr2873

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