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Coffee consumption modifies risk of estrogen-receptor negative breast cancer
INTRODUCTION: Breast cancer is a complex disease and may be sub-divided into hormone-responsive (estrogen receptor (ER) positive) and non-hormone-responsive subtypes (ER-negative). Some evidence suggests that heterogeneity exists in the associations between coffee consumption and breast cancer risk,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218935/ https://www.ncbi.nlm.nih.gov/pubmed/21569535 http://dx.doi.org/10.1186/bcr2879 |
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author | Li, Jingmei Seibold, Petra Chang-Claude, Jenny Flesch-Janys, Dieter Liu, Jianjun Czene, Kamila Humphreys, Keith Hall, Per |
author_facet | Li, Jingmei Seibold, Petra Chang-Claude, Jenny Flesch-Janys, Dieter Liu, Jianjun Czene, Kamila Humphreys, Keith Hall, Per |
author_sort | Li, Jingmei |
collection | PubMed |
description | INTRODUCTION: Breast cancer is a complex disease and may be sub-divided into hormone-responsive (estrogen receptor (ER) positive) and non-hormone-responsive subtypes (ER-negative). Some evidence suggests that heterogeneity exists in the associations between coffee consumption and breast cancer risk, according to different estrogen receptor subtypes. We assessed the association between coffee consumption and postmenopausal breast cancer risk in a large population-based study (2,818 cases and 3,111 controls), overall, and stratified by ER tumour subtypes. METHODS: Odds ratios (OR) and corresponding 95% confidence intervals (CI) were estimated using the multivariate logistic regression models fitted to examine breast cancer risk in a stratified case-control analysis. Heterogeneity among ER subtypes was evaluated in a case-only analysis, by fitting binary logistic regression models, treating ER status as a dependent variable, with coffee consumption included as a covariate. RESULTS: In the Swedish study, coffee consumption was associated with a modest decrease in overall breast cancer risk in the age-adjusted model (OR(> 5 cups/day )compared to OR(≤ 1 cup/day): 0.80, 95% CI: 0.64, 0.99, P trend = 0.028). In the stratified case-control analyses, a significant reduction in the risk of ER-negative breast cancer was observed in heavy coffee drinkers (OR(> 5 cups/day )compared to OR(≤ 1 cup/day ): 0.43, 95% CI: 0.25, 0.72, P trend = 0.0003) in a multivariate-adjusted model. The breast cancer risk reduction associated with higher coffee consumption was significantly higher for ER-negative compared to ER-positive tumours (P heterogeneity (age-adjusted) = 0.004). CONCLUSIONS: A high daily intake of coffee was found to be associated with a statistically significant decrease in ER-negative breast cancer among postmenopausal women. |
format | Online Article Text |
id | pubmed-3218935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32189352011-11-18 Coffee consumption modifies risk of estrogen-receptor negative breast cancer Li, Jingmei Seibold, Petra Chang-Claude, Jenny Flesch-Janys, Dieter Liu, Jianjun Czene, Kamila Humphreys, Keith Hall, Per Breast Cancer Res Research Article INTRODUCTION: Breast cancer is a complex disease and may be sub-divided into hormone-responsive (estrogen receptor (ER) positive) and non-hormone-responsive subtypes (ER-negative). Some evidence suggests that heterogeneity exists in the associations between coffee consumption and breast cancer risk, according to different estrogen receptor subtypes. We assessed the association between coffee consumption and postmenopausal breast cancer risk in a large population-based study (2,818 cases and 3,111 controls), overall, and stratified by ER tumour subtypes. METHODS: Odds ratios (OR) and corresponding 95% confidence intervals (CI) were estimated using the multivariate logistic regression models fitted to examine breast cancer risk in a stratified case-control analysis. Heterogeneity among ER subtypes was evaluated in a case-only analysis, by fitting binary logistic regression models, treating ER status as a dependent variable, with coffee consumption included as a covariate. RESULTS: In the Swedish study, coffee consumption was associated with a modest decrease in overall breast cancer risk in the age-adjusted model (OR(> 5 cups/day )compared to OR(≤ 1 cup/day): 0.80, 95% CI: 0.64, 0.99, P trend = 0.028). In the stratified case-control analyses, a significant reduction in the risk of ER-negative breast cancer was observed in heavy coffee drinkers (OR(> 5 cups/day )compared to OR(≤ 1 cup/day ): 0.43, 95% CI: 0.25, 0.72, P trend = 0.0003) in a multivariate-adjusted model. The breast cancer risk reduction associated with higher coffee consumption was significantly higher for ER-negative compared to ER-positive tumours (P heterogeneity (age-adjusted) = 0.004). CONCLUSIONS: A high daily intake of coffee was found to be associated with a statistically significant decrease in ER-negative breast cancer among postmenopausal women. BioMed Central 2011 2011-05-14 /pmc/articles/PMC3218935/ /pubmed/21569535 http://dx.doi.org/10.1186/bcr2879 Text en Copyright ©2011 Li et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Li, Jingmei Seibold, Petra Chang-Claude, Jenny Flesch-Janys, Dieter Liu, Jianjun Czene, Kamila Humphreys, Keith Hall, Per Coffee consumption modifies risk of estrogen-receptor negative breast cancer |
title | Coffee consumption modifies risk of estrogen-receptor negative breast cancer |
title_full | Coffee consumption modifies risk of estrogen-receptor negative breast cancer |
title_fullStr | Coffee consumption modifies risk of estrogen-receptor negative breast cancer |
title_full_unstemmed | Coffee consumption modifies risk of estrogen-receptor negative breast cancer |
title_short | Coffee consumption modifies risk of estrogen-receptor negative breast cancer |
title_sort | coffee consumption modifies risk of estrogen-receptor negative breast cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218935/ https://www.ncbi.nlm.nih.gov/pubmed/21569535 http://dx.doi.org/10.1186/bcr2879 |
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