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Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes

INTRODUCTION: Insulin-like growth factor 1 (IGF-1) receptor (IGF-1R) is phosphorylated in all breast cancer subtypes. Past findings have shown that IGF-1R mediates antiestrogen resistance through cross-talk with estrogen receptor (ER) signaling and via its action upstream of the epidermal growth fac...

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Detalles Bibliográficos
Autores principales:	Zhang, Yinghui, Moerkens, Marja, Ramaiahgari, Sreenivasa, de Bont, Hans, Price, Leo, Meerman, John, van de Water, Bob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218939/ https://www.ncbi.nlm.nih.gov/pubmed/21595894 http://dx.doi.org/10.1186/bcr2883

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