Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells

INTRODUCTION: The nuclear enzyme topoisomerase IIα (TopoIIα) is able to cleave DNA in a reversible manner, making it a valuable target for agents such as etoposide that trap the enzyme in a covalent bond with the 5′ DNA end to which it cleaves. This prevents DNA religation and triggers cell death in...

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Detalles Bibliográficos
Autores principales: Gardner, Lauren, Malik, Rohit, Shimizu, Yoshiko, Mullins, Nicole, ElShamy, Wael M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218940/
https://www.ncbi.nlm.nih.gov/pubmed/21595939
http://dx.doi.org/10.1186/bcr2884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218940/
https://www.ncbi.nlm.nih.gov/pubmed/21595939
http://dx.doi.org/10.1186/bcr2884

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