miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype

Decreased expression of miRNAs of the miR-200 family has been implicated in the growth and metastasis of breast cancer cells. Of this family, miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2, mediators of epithelial- mesenchymal transition. An articl...

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Detalles Bibliográficos
Autor principal: Radisky, Derek C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218941/
https://www.ncbi.nlm.nih.gov/pubmed/21682933
http://dx.doi.org/10.1186/bcr2885
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author Radisky, Derek C
author_facet Radisky, Derek C
author_sort Radisky, Derek C
collection PubMed
description Decreased expression of miRNAs of the miR-200 family has been implicated in the growth and metastasis of breast cancer cells. Of this family, miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2, mediators of epithelial- mesenchymal transition. An article in the previous issue of Breast Cancer Research identifies additional targets of miR-200c that link increased cancer cell invasiveness, resistance to apoptosis, and induction of breast cancer stem cell characteristics.
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spelling pubmed-32189412011-12-10 miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype Radisky, Derek C Breast Cancer Res Editorial Decreased expression of miRNAs of the miR-200 family has been implicated in the growth and metastasis of breast cancer cells. Of this family, miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2, mediators of epithelial- mesenchymal transition. An article in the previous issue of Breast Cancer Research identifies additional targets of miR-200c that link increased cancer cell invasiveness, resistance to apoptosis, and induction of breast cancer stem cell characteristics. BioMed Central 2011 2011-06-10 /pmc/articles/PMC3218941/ /pubmed/21682933 http://dx.doi.org/10.1186/bcr2885 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Editorial
Radisky, Derek C
miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype
title miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype
title_full miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype
title_fullStr miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype
title_full_unstemmed miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype
title_short miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype
title_sort mir-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218941/
https://www.ncbi.nlm.nih.gov/pubmed/21682933
http://dx.doi.org/10.1186/bcr2885
work_keys_str_mv AT radiskyderekc mir200catthenexusofepithelialmesenchymaltransitionresistancetoapoptosisandthebreastcancerstemcellphenotype

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