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Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silico based mechanism

INTRODUCTION: Human epidermal growth factor 2 (Her2), a receptor tyrosine kinase, is overexpressed in breast cancers. It has been successfully targeted by small molecule kinase inhibitors and by antibodies. Recent clinical data show a synergistic response in patients when two antibodies, trastuzumab...

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Detalles Bibliográficos
Autores principales:	Fuentes, Gloria, Scaltriti, Maurizio, Baselga, José, Verma, Chandra S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218942/ https://www.ncbi.nlm.nih.gov/pubmed/21600050 http://dx.doi.org/10.1186/bcr2888

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