Cargando…

Bench-to-bedside review: Contrast enhanced ultrasonography - a promising technique to assess renal perfusion in the ICU

Acute kidney injury (AKI) is common in critically ill patients and associated with important morbidity and mortality. Although alterations in renal perfusion are thought to play a causative role in the pathogenesis of AKI, there is, to date, no reliable technique that allows the assessment of renal...

Descripción completa

Detalles Bibliográficos
Autores principales: Schneider, Antoine, Johnson, Lynne, Goodwin, Mark, Schelleman, Anthony, Bellomo, Rinaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218962/
https://www.ncbi.nlm.nih.gov/pubmed/21586101
http://dx.doi.org/10.1186/cc10058
_version_ 1782216767337136128
author Schneider, Antoine
Johnson, Lynne
Goodwin, Mark
Schelleman, Anthony
Bellomo, Rinaldo
author_facet Schneider, Antoine
Johnson, Lynne
Goodwin, Mark
Schelleman, Anthony
Bellomo, Rinaldo
author_sort Schneider, Antoine
collection PubMed
description Acute kidney injury (AKI) is common in critically ill patients and associated with important morbidity and mortality. Although alterations in renal perfusion are thought to play a causative role in the pathogenesis of AKI, there is, to date, no reliable technique that allows the assessment of renal perfusion that is applicable in the ICU. Contrast-enhanced ultrasound (CEUS) is an ultrasound imaging technique that makes use of microbubble-based contrast agents. These microbubbles, when injected into the bloodstream, allow visualization of vascular structures and, with contrast-specific imaging modes, detection of blood flow at the capillary level. Some recent CEUS-derived approaches allow quantification of blood flow in several organs, including the kidney. Current generation ultrasound contrast agents have strong stability and safety profiles. Along with post-marketing surveillance, numerous studies report safe administration of these agents, including in critically ill patients. This review presents information on the physical principles underlying CEUS, the methods allowing blood flow quantification and the potential applications of CEUS in critical care nephrology, currently as a research tool but perhaps in the future as a way of monitoring renal perfusion.
format Online
Article
Text
id pubmed-3218962
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-32189622012-05-06 Bench-to-bedside review: Contrast enhanced ultrasonography - a promising technique to assess renal perfusion in the ICU Schneider, Antoine Johnson, Lynne Goodwin, Mark Schelleman, Anthony Bellomo, Rinaldo Crit Care Review Acute kidney injury (AKI) is common in critically ill patients and associated with important morbidity and mortality. Although alterations in renal perfusion are thought to play a causative role in the pathogenesis of AKI, there is, to date, no reliable technique that allows the assessment of renal perfusion that is applicable in the ICU. Contrast-enhanced ultrasound (CEUS) is an ultrasound imaging technique that makes use of microbubble-based contrast agents. These microbubbles, when injected into the bloodstream, allow visualization of vascular structures and, with contrast-specific imaging modes, detection of blood flow at the capillary level. Some recent CEUS-derived approaches allow quantification of blood flow in several organs, including the kidney. Current generation ultrasound contrast agents have strong stability and safety profiles. Along with post-marketing surveillance, numerous studies report safe administration of these agents, including in critically ill patients. This review presents information on the physical principles underlying CEUS, the methods allowing blood flow quantification and the potential applications of CEUS in critical care nephrology, currently as a research tool but perhaps in the future as a way of monitoring renal perfusion. BioMed Central 2011 2011-05-06 /pmc/articles/PMC3218962/ /pubmed/21586101 http://dx.doi.org/10.1186/cc10058 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Review
Schneider, Antoine
Johnson, Lynne
Goodwin, Mark
Schelleman, Anthony
Bellomo, Rinaldo
Bench-to-bedside review: Contrast enhanced ultrasonography - a promising technique to assess renal perfusion in the ICU
title Bench-to-bedside review: Contrast enhanced ultrasonography - a promising technique to assess renal perfusion in the ICU
title_full Bench-to-bedside review: Contrast enhanced ultrasonography - a promising technique to assess renal perfusion in the ICU
title_fullStr Bench-to-bedside review: Contrast enhanced ultrasonography - a promising technique to assess renal perfusion in the ICU
title_full_unstemmed Bench-to-bedside review: Contrast enhanced ultrasonography - a promising technique to assess renal perfusion in the ICU
title_short Bench-to-bedside review: Contrast enhanced ultrasonography - a promising technique to assess renal perfusion in the ICU
title_sort bench-to-bedside review: contrast enhanced ultrasonography - a promising technique to assess renal perfusion in the icu
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218962/
https://www.ncbi.nlm.nih.gov/pubmed/21586101
http://dx.doi.org/10.1186/cc10058
work_keys_str_mv AT schneiderantoine benchtobedsidereviewcontrastenhancedultrasonographyapromisingtechniquetoassessrenalperfusionintheicu
AT johnsonlynne benchtobedsidereviewcontrastenhancedultrasonographyapromisingtechniquetoassessrenalperfusionintheicu
AT goodwinmark benchtobedsidereviewcontrastenhancedultrasonographyapromisingtechniquetoassessrenalperfusionintheicu
AT schellemananthony benchtobedsidereviewcontrastenhancedultrasonographyapromisingtechniquetoassessrenalperfusionintheicu
AT bellomorinaldo benchtobedsidereviewcontrastenhancedultrasonographyapromisingtechniquetoassessrenalperfusionintheicu