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The lung and the brain: a dangerous cross-talk

Brain or lung injury or both are frequent causes of admission to intensive care units and are associated with high morbidity and mortality rates. Mechanical ventilation, which is commonly used in the management of these critically ill patients, can induce an inflammatory response, which may be invol...

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Detalles Bibliográficos
Autores principales: Pelosi, Paolo, Rocco, Patricia RM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219008/
https://www.ncbi.nlm.nih.gov/pubmed/21722336
http://dx.doi.org/10.1186/cc10259
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author Pelosi, Paolo
Rocco, Patricia RM
author_facet Pelosi, Paolo
Rocco, Patricia RM
author_sort Pelosi, Paolo
collection PubMed
description Brain or lung injury or both are frequent causes of admission to intensive care units and are associated with high morbidity and mortality rates. Mechanical ventilation, which is commonly used in the management of these critically ill patients, can induce an inflammatory response, which may be involved in distal organ failure. Thus, there may be a complex crosstalk between the lungs and other organs, including the brain. Interestingly, survivors from acute lung injury/acute respiratory distress syndrome frequently have some cognitive deterioration at hospital discharge. Such neurologic dysfunction might be a secondary marker of injury and the neuroanatomical substrate for downstream impairment of other organs. Brainlung interactions have received little attention in the literature, but recent evidence suggests that both the lungs and brain can promote inflammation through common mediators. The present commentary discusses the main physiological issues related to brain-lung interactions.
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spelling pubmed-32190082012-06-30 The lung and the brain: a dangerous cross-talk Pelosi, Paolo Rocco, Patricia RM Crit Care Commentary Brain or lung injury or both are frequent causes of admission to intensive care units and are associated with high morbidity and mortality rates. Mechanical ventilation, which is commonly used in the management of these critically ill patients, can induce an inflammatory response, which may be involved in distal organ failure. Thus, there may be a complex crosstalk between the lungs and other organs, including the brain. Interestingly, survivors from acute lung injury/acute respiratory distress syndrome frequently have some cognitive deterioration at hospital discharge. Such neurologic dysfunction might be a secondary marker of injury and the neuroanatomical substrate for downstream impairment of other organs. Brainlung interactions have received little attention in the literature, but recent evidence suggests that both the lungs and brain can promote inflammation through common mediators. The present commentary discusses the main physiological issues related to brain-lung interactions. BioMed Central 2011 2011-06-30 /pmc/articles/PMC3219008/ /pubmed/21722336 http://dx.doi.org/10.1186/cc10259 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Commentary
Pelosi, Paolo
Rocco, Patricia RM
The lung and the brain: a dangerous cross-talk
title The lung and the brain: a dangerous cross-talk
title_full The lung and the brain: a dangerous cross-talk
title_fullStr The lung and the brain: a dangerous cross-talk
title_full_unstemmed The lung and the brain: a dangerous cross-talk
title_short The lung and the brain: a dangerous cross-talk
title_sort lung and the brain: a dangerous cross-talk
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219008/
https://www.ncbi.nlm.nih.gov/pubmed/21722336
http://dx.doi.org/10.1186/cc10259
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