Cargando…
Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation
Stimulation of CD95/Fas/APO-1 results in the induction of both apoptotic and non-apoptotic signaling pathways. The processes regulating these two opposing pathways have not been thoroughly elucidated to date. In this study, using quantitative immunoblots, imaging, and mathematical modeling, we addre...
Autores principales: | Kober, A M M, Legewie, S, Pforr, C, Fricker, N, Eils, R, Krammer, P H, Lavrik, I N |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219090/ https://www.ncbi.nlm.nih.gov/pubmed/21975294 http://dx.doi.org/10.1038/cddis.2011.93 |
Ejemplares similares
-
Dynamics within the CD95 death-inducing signaling complex decide life and death of cells
por: Neumann, Leo, et al.
Publicado: (2010) -
Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIP(L)
por: Fricker, Nicolai, et al.
Publicado: (2010) -
Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis
por: Bentele, M., et al.
Publicado: (2004) -
Caspase-10-Dependent Cell Death in Fas/CD95 Signalling Is Not Abrogated by Caspase Inhibitor zVAD-fmk
por: Lafont, Elodie, et al.
Publicado: (2010) -
The chains of death: A new view on caspase-8 activation at the DISC
por: Schleich, Kolja, et al.
Publicado: (2013)