Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice

INTRODUCTION: Women who carry a BRCA1 mutation typically develop "triple-negative" breast cancers (TNBC), defined by the absence of estrogen receptor (ER), progesterone receptor and Her2/neu. In contrast to ER-positive tumors, TNBCs frequently express high levels of epidermal growth factor...

Descripción completa

Detalles Bibliográficos
Autores principales: Burga, Laura N, Hu, Hai, Juvekar, Ashish, Tung, Nadine M, Troyan, Susan L, Hofstatter, Erin W, Wulf, Gerburg M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219192/
https://www.ncbi.nlm.nih.gov/pubmed/21396117
http://dx.doi.org/10.1186/bcr2850

Ejemplares similares

Ejemplares similares