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Septic-associated encephalopathy - everything starts at a microlevel

Sepsis-associated encephalopathy is associated with increased mortality and morbidity. Its pathophysiology remains insufficiently elucidated, although there is evidence for a neuroinflammatory process sequentially involving endothelial activation, blood-brain barrier alteration and cellular dysfunct...

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Detalles Bibliográficos
Autores principales: Sharshar, Tarek, Polito, Andrea, Checinski, Anthony, Stevens, Robert D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219258/
https://www.ncbi.nlm.nih.gov/pubmed/21067627
http://dx.doi.org/10.1186/cc9254
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author Sharshar, Tarek
Polito, Andrea
Checinski, Anthony
Stevens, Robert D
author_facet Sharshar, Tarek
Polito, Andrea
Checinski, Anthony
Stevens, Robert D
author_sort Sharshar, Tarek
collection PubMed
description Sepsis-associated encephalopathy is associated with increased mortality and morbidity. Its pathophysiology remains insufficiently elucidated, although there is evidence for a neuroinflammatory process sequentially involving endothelial activation, blood-brain barrier alteration and cellular dysfunction and alteration in neurotransmission. Experimental studies have shown that microcirculatory dysfunction, a consequence of endothelial activation, is an early pathogenic step. To date, we do not know whether it is present in septic patients, whether it accounts for clinical features and whether it is treatable.
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spelling pubmed-32192582011-11-18 Septic-associated encephalopathy - everything starts at a microlevel Sharshar, Tarek Polito, Andrea Checinski, Anthony Stevens, Robert D Crit Care Commentary Sepsis-associated encephalopathy is associated with increased mortality and morbidity. Its pathophysiology remains insufficiently elucidated, although there is evidence for a neuroinflammatory process sequentially involving endothelial activation, blood-brain barrier alteration and cellular dysfunction and alteration in neurotransmission. Experimental studies have shown that microcirculatory dysfunction, a consequence of endothelial activation, is an early pathogenic step. To date, we do not know whether it is present in septic patients, whether it accounts for clinical features and whether it is treatable. BioMed Central 2010 2010-09-29 /pmc/articles/PMC3219258/ /pubmed/21067627 http://dx.doi.org/10.1186/cc9254 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Commentary
Sharshar, Tarek
Polito, Andrea
Checinski, Anthony
Stevens, Robert D
Septic-associated encephalopathy - everything starts at a microlevel
title Septic-associated encephalopathy - everything starts at a microlevel
title_full Septic-associated encephalopathy - everything starts at a microlevel
title_fullStr Septic-associated encephalopathy - everything starts at a microlevel
title_full_unstemmed Septic-associated encephalopathy - everything starts at a microlevel
title_short Septic-associated encephalopathy - everything starts at a microlevel
title_sort septic-associated encephalopathy - everything starts at a microlevel
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219258/
https://www.ncbi.nlm.nih.gov/pubmed/21067627
http://dx.doi.org/10.1186/cc9254
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