Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating

Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below disease threshold has not been studied...

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Autores principales: Nopoulos, Peg, Epping, Eric A, Wassink, Tom, Schlaggar, Bradley L, Perlmutter, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Short Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219594/
https://www.ncbi.nlm.nih.gov/pubmed/22008211
http://dx.doi.org/10.1186/1744-9081-7-45
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author Nopoulos, Peg
Epping, Eric A
Wassink, Tom
Schlaggar, Bradley L
Perlmutter, Joel
author_facet Nopoulos, Peg
Epping, Eric A
Wassink, Tom
Schlaggar, Bradley L
Perlmutter, Joel
author_sort Nopoulos, Peg
collection PubMed
description Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below disease threshold has not been studied. The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating.
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spelling pubmed-32195942011-11-18 Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating Nopoulos, Peg Epping, Eric A Wassink, Tom Schlaggar, Bradley L Perlmutter, Joel Behav Brain Funct Short Paper Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below disease threshold has not been studied. The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating. BioMed Central 2011-10-18 /pmc/articles/PMC3219594/ /pubmed/22008211 http://dx.doi.org/10.1186/1744-9081-7-45 Text en Copyright ©2011 Nopoulos et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Paper
Nopoulos, Peg
Epping, Eric A
Wassink, Tom
Schlaggar, Bradley L
Perlmutter, Joel
Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
title Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
title_full Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
title_fullStr Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
title_full_unstemmed Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
title_short Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
title_sort correlation of cag repeat length between the maternal and paternal allele of the huntingtin gene: evidence for assortative mating
topic Short Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219594/
https://www.ncbi.nlm.nih.gov/pubmed/22008211
http://dx.doi.org/10.1186/1744-9081-7-45
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