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The NF1 Gene Contains Hotspots for L1 Endonuclease-Dependent De Novo Insertion

Long interspersed (L1) and Alu elements are actively amplified in the human genome through retrotransposition of their RNA intermediates by the ∼100 still retrotranspositionally fully competent L1 elements. Retrotransposition can cause inherited disease if such an element is inserted near or within...

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Detalles Bibliográficos
Autores principales:	Wimmer, Katharina, Callens, Tom, Wernstedt, Annekatrin, Messiaen, Ludwine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219598/ https://www.ncbi.nlm.nih.gov/pubmed/22125493 http://dx.doi.org/10.1371/journal.pgen.1002371

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