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Deciphering the Arginine-Binding Preferences at the Substrate-Binding Groove of Ser/Thr Kinases by Computational Surface Mapping

Protein kinases are key signaling enzymes that catalyze the transfer of γ-phosphate from an ATP molecule to a phospho-accepting residue in the substrate. Unraveling the molecular features that govern the preference of kinases for particular residues flanking the phosphoacceptor is important for unde...

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Detalles Bibliográficos
Autores principales: Ben-Shimon, Avraham, Niv, Masha Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219626/
https://www.ncbi.nlm.nih.gov/pubmed/22125489
http://dx.doi.org/10.1371/journal.pcbi.1002288

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