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Molecular Pathogenesis of Secondary Acute Promyelocytic Leukemia

Balanced chromosomal translocations that generate chimeric oncoproteins are considered to be initiating lesions in the pathogenesis of acute myeloid leukemia. The most frequent is the t(15;17)(q22;q21), which fuses the PML and RARA genes, giving rise to acute promyelocytic leukemia (APL). An increas...

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Detalles Bibliográficos
Autores principales:	Joannides, M., Mays, A. N., Mistry, A. R., Hasan, S. K., Reiter, A., Wiemels, J. L., Felix, C. A., Coco, F. Lo, Osheroff, N., Solomon, E., Grimwade, D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Università Cattolica del Sacro Cuore 2011
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219647/ https://www.ncbi.nlm.nih.gov/pubmed/22110895 http://dx.doi.org/10.4084/MJHID.2011.045

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