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Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects
BACKGROUND: Phosphodiesterase 4 (PDE4) inhibitors increase intracellular cyclic adenosine monophosphate (cAMP), leading to regulation of inflammatory cell functions. Roflumilast is a potent and targeted PDE4 inhibitor. The objective of this study was to evaluate the effects of roflumilast on broncho...
Autores principales: | Gauvreau, Gail M, Boulet, Louis-Philippe, Schmid-Wirlitsch, Christine, Côté, Johanne, Duong, MyLinh, Killian, Kieran J, Milot, Joanne, Deschesnes, Francine, Strinich, Tara, Watson, Richard M, Bredenbröker, Dirk, O'Byrne, Paul M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219708/ https://www.ncbi.nlm.nih.gov/pubmed/22029856 http://dx.doi.org/10.1186/1465-9921-12-140 |
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