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Ultra-Efficient PrP(Sc) Amplification Highlights Potentialities and Pitfalls of PMCA Technology

In order to investigate the potential of voles to reproduce in vitro the efficiency of prion replication previously observed in vivo, we seeded protein misfolding cyclic amplification (PMCA) reactions with either rodent-adapted Transmissible Spongiform Encephalopathy (TSE) strains or natural TSE iso...

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Detalles Bibliográficos
Autores principales:	Cosseddu, Gian Mario, Nonno, Romolo, Vaccari, Gabriele, Bucalossi, Cecilia, Fernandez-Borges, Natalia, Di Bari, Michele Angelo, Castilla, Joaquin, Agrimi, Umberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219717/ https://www.ncbi.nlm.nih.gov/pubmed/22114554 http://dx.doi.org/10.1371/journal.ppat.1002370

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