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Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrP(Sc) Accumulation

During prion infections of the central nervous system (CNS) the cellular prion protein, PrP(C), is templated to a conformationally distinct form, PrP(Sc). Recent studies have demonstrated that the Sprn gene encodes a GPI-linked glycoprotein Shadoo (Sho), which localizes to a similar membrane environ...

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Detalles Bibliográficos
Autores principales:	Westaway, David, Genovesi, Sacha, Daude, Nathalie, Brown, Rebecca, Lau, Agnes, Lee, Inyoul, Mays, Charles E., Coomaraswamy, Janaky, Canine, Brenda, Pitstick, Rose, Herbst, Allen, Yang, Jing, Ko, Kerry W. S., Schmitt-Ulms, Gerold, DeArmond, Stephen J., McKenzie, Debbie, Hood, Leroy, Carlson, George A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219720/ https://www.ncbi.nlm.nih.gov/pubmed/22114562 http://dx.doi.org/10.1371/journal.ppat.1002391

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