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Protease-Resistant Prions Selectively Decrease Shadoo Protein

The central event in prion diseases is the conformational conversion of the cellular prion protein (PrP(C)) into PrP(Sc), a partially protease-resistant and infectious conformer. However, the mechanism by which PrP(Sc) causes neuronal dysfunction remains poorly understood. Levels of Shadoo (Sho), a...

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Detalles Bibliográficos
Autores principales:	Watts, Joel C., Stöhr, Jan, Bhardwaj, Sumita, Wille, Holger, Oehler, Abby, DeArmond, Stephen J., Giles, Kurt, Prusiner, Stanley B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219722/ https://www.ncbi.nlm.nih.gov/pubmed/22163178 http://dx.doi.org/10.1371/journal.ppat.1002382

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