Evolution of a Species-Specific Determinant within Human CRM1 that Regulates the Post-transcriptional Phases of HIV-1 Replication

The human immunodeficiency virus type-1 (HIV-1) Rev protein regulates the nuclear export of intron-containing viral RNAs by recruiting the CRM1 nuclear export receptor. Here, we employed a combination of functional and phylogenetic analyses to identify and characterize a species-specific determinant...

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Detalles Bibliográficos
Autores principales: Sherer, Nathan M., Swanson, Chad M., Hué, Stéphane, Roberts, Roland G., Bergeron, Julien R. C., Malim, Michael H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219727/
https://www.ncbi.nlm.nih.gov/pubmed/22114565
http://dx.doi.org/10.1371/journal.ppat.1002395

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