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Evaluation of atherosclerotic findings in patients with nonalcoholic fatty liver disease

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), a highly prevalent condition, is a feature of metabolic syndrome and is characterized by excessive accumulation of fat in the liver cells. The purpose of this study was to investigate the association between NAFLD and carotid intima-media thickne...

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Autores principales: Mohammadi, Afshin, Bazazi, Ali, Ghasemi-rad, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219757/
https://www.ncbi.nlm.nih.gov/pubmed/22114515
http://dx.doi.org/10.2147/IJGM.S25753
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author Mohammadi, Afshin
Bazazi, Ali
Ghasemi-rad, Mohammad
author_facet Mohammadi, Afshin
Bazazi, Ali
Ghasemi-rad, Mohammad
author_sort Mohammadi, Afshin
collection PubMed
description BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), a highly prevalent condition, is a feature of metabolic syndrome and is characterized by excessive accumulation of fat in the liver cells. The purpose of this study was to investigate the association between NAFLD and carotid intima-media thickness (CIMT) as an independent risk factor for atherosclerosis. METHODS: We examined 250 consecutive patients with ultrasonographically confirmed NAFLD and 85 age-matched and gender-matched controls with normal parenchymal liver echogenicity for determination of CIMT and presence of carotid atherosclerotic plaque. RESULTS: Compared with control subjects, patients with NAFLD showed an increased mean CIMT (0.81 ± 0.14 mm) compared with control subjects (0.58 ± 0.15 mm). This difference was statistically significant (P = 0.001). After performing multivariate analysis, the presence of NAFLD was associated with abnormal CIMT independent of other atherogenic risk factors or its association with metabolic syndrome. CONCLUSION: NAFLD can be an independent risk factor for developing atherosclerosis. Therefore, NAFLD with and without metabolic syndrome can be associated with increased CIMT and increased risk of cardiovascular events in patients with NAFLD incidentally diagnosed on abdominal ultrasonography.
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spelling pubmed-32197572011-11-23 Evaluation of atherosclerotic findings in patients with nonalcoholic fatty liver disease Mohammadi, Afshin Bazazi, Ali Ghasemi-rad, Mohammad Int J Gen Med Original Research BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), a highly prevalent condition, is a feature of metabolic syndrome and is characterized by excessive accumulation of fat in the liver cells. The purpose of this study was to investigate the association between NAFLD and carotid intima-media thickness (CIMT) as an independent risk factor for atherosclerosis. METHODS: We examined 250 consecutive patients with ultrasonographically confirmed NAFLD and 85 age-matched and gender-matched controls with normal parenchymal liver echogenicity for determination of CIMT and presence of carotid atherosclerotic plaque. RESULTS: Compared with control subjects, patients with NAFLD showed an increased mean CIMT (0.81 ± 0.14 mm) compared with control subjects (0.58 ± 0.15 mm). This difference was statistically significant (P = 0.001). After performing multivariate analysis, the presence of NAFLD was associated with abnormal CIMT independent of other atherogenic risk factors or its association with metabolic syndrome. CONCLUSION: NAFLD can be an independent risk factor for developing atherosclerosis. Therefore, NAFLD with and without metabolic syndrome can be associated with increased CIMT and increased risk of cardiovascular events in patients with NAFLD incidentally diagnosed on abdominal ultrasonography. Dove Medical Press 2011-10-25 /pmc/articles/PMC3219757/ /pubmed/22114515 http://dx.doi.org/10.2147/IJGM.S25753 Text en © 2011 Mohammadi et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Mohammadi, Afshin
Bazazi, Ali
Ghasemi-rad, Mohammad
Evaluation of atherosclerotic findings in patients with nonalcoholic fatty liver disease
title Evaluation of atherosclerotic findings in patients with nonalcoholic fatty liver disease
title_full Evaluation of atherosclerotic findings in patients with nonalcoholic fatty liver disease
title_fullStr Evaluation of atherosclerotic findings in patients with nonalcoholic fatty liver disease
title_full_unstemmed Evaluation of atherosclerotic findings in patients with nonalcoholic fatty liver disease
title_short Evaluation of atherosclerotic findings in patients with nonalcoholic fatty liver disease
title_sort evaluation of atherosclerotic findings in patients with nonalcoholic fatty liver disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219757/
https://www.ncbi.nlm.nih.gov/pubmed/22114515
http://dx.doi.org/10.2147/IJGM.S25753
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