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Analgesic effect of preoperative versus intraoperative dexamethasone after laparoscopic cholecystectomy with multimodal analgesia

BACKGROUND: Pain after laparoscopy is multifactorial and different treatments have been proposed to provide pain relief. Multimodal analgesia is now recommended to prevent and treat post-laparoscopy pain. Dexamethasone is effective in reducing postoperative pain. The timing of steroid administration...

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Autores principales: Lim, Se Hun, Jang, Eun Ho, Kim, Myoung-Hun, Cho, Kwangrae, Lee, Jeong Han, Lee, Kun Moo, Cheong, Soon Ho, Kim, Young-Jae, Shin, Chee-Mahn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Anesthesiologists 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219778/
https://www.ncbi.nlm.nih.gov/pubmed/22110885
http://dx.doi.org/10.4097/kjae.2011.61.4.315
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author Lim, Se Hun
Jang, Eun Ho
Kim, Myoung-Hun
Cho, Kwangrae
Lee, Jeong Han
Lee, Kun Moo
Cheong, Soon Ho
Kim, Young-Jae
Shin, Chee-Mahn
author_facet Lim, Se Hun
Jang, Eun Ho
Kim, Myoung-Hun
Cho, Kwangrae
Lee, Jeong Han
Lee, Kun Moo
Cheong, Soon Ho
Kim, Young-Jae
Shin, Chee-Mahn
author_sort Lim, Se Hun
collection PubMed
description BACKGROUND: Pain after laparoscopy is multifactorial and different treatments have been proposed to provide pain relief. Multimodal analgesia is now recommended to prevent and treat post-laparoscopy pain. Dexamethasone is effective in reducing postoperative pain. The timing of steroid administration seems to be important. We evaluated the analgesic efficacy of preoperative intravenous dexamethasone 1 hour before versus during laparoscopic cholecystectomy with multimodal analgesia. METHODS: One hundred twenty patients aged 20 to 65 years old were allocated randomly into one of three groups (n = 40, in each). The patients in the group N received normal saline 1 hour before induction and after the resection of gall bladder. The patients in the group S1 received dexamethasone 8 mg 1 hour before induction and normal saline after the resection of gall bladder. The patients in the group S2 received normal saline 1 hour before induction and dexamethasone 8 mg after the resection of gall bladder. RESULTS: VAS scores of group S1 and S2 were lower than that of group N during 48 hours after laparoscopic cholecystectomy. There were no significant differences of VAS scores between the group S1 and the group S2. The analgesic consumption of group S1 and S2 were significantly lower than that of group N. CONCLUSIONS: A single dose of dexamethasone (8 mg) intravenously given 1 hour before induction or during operation was effective in reducing postoperative pain after laparoscopic cholecystectomy with multimodal analgesia. The analgesic efficacy of preoperative intravenous dexamethasone 1 hour before versus during surgery was not significantly different.
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spelling pubmed-32197782011-11-22 Analgesic effect of preoperative versus intraoperative dexamethasone after laparoscopic cholecystectomy with multimodal analgesia Lim, Se Hun Jang, Eun Ho Kim, Myoung-Hun Cho, Kwangrae Lee, Jeong Han Lee, Kun Moo Cheong, Soon Ho Kim, Young-Jae Shin, Chee-Mahn Korean J Anesthesiol Clinical Research Article BACKGROUND: Pain after laparoscopy is multifactorial and different treatments have been proposed to provide pain relief. Multimodal analgesia is now recommended to prevent and treat post-laparoscopy pain. Dexamethasone is effective in reducing postoperative pain. The timing of steroid administration seems to be important. We evaluated the analgesic efficacy of preoperative intravenous dexamethasone 1 hour before versus during laparoscopic cholecystectomy with multimodal analgesia. METHODS: One hundred twenty patients aged 20 to 65 years old were allocated randomly into one of three groups (n = 40, in each). The patients in the group N received normal saline 1 hour before induction and after the resection of gall bladder. The patients in the group S1 received dexamethasone 8 mg 1 hour before induction and normal saline after the resection of gall bladder. The patients in the group S2 received normal saline 1 hour before induction and dexamethasone 8 mg after the resection of gall bladder. RESULTS: VAS scores of group S1 and S2 were lower than that of group N during 48 hours after laparoscopic cholecystectomy. There were no significant differences of VAS scores between the group S1 and the group S2. The analgesic consumption of group S1 and S2 were significantly lower than that of group N. CONCLUSIONS: A single dose of dexamethasone (8 mg) intravenously given 1 hour before induction or during operation was effective in reducing postoperative pain after laparoscopic cholecystectomy with multimodal analgesia. The analgesic efficacy of preoperative intravenous dexamethasone 1 hour before versus during surgery was not significantly different. The Korean Society of Anesthesiologists 2011-10 2011-10-22 /pmc/articles/PMC3219778/ /pubmed/22110885 http://dx.doi.org/10.4097/kjae.2011.61.4.315 Text en Copyright © the Korean Society of Anesthesiologists, 2011 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Article
Lim, Se Hun
Jang, Eun Ho
Kim, Myoung-Hun
Cho, Kwangrae
Lee, Jeong Han
Lee, Kun Moo
Cheong, Soon Ho
Kim, Young-Jae
Shin, Chee-Mahn
Analgesic effect of preoperative versus intraoperative dexamethasone after laparoscopic cholecystectomy with multimodal analgesia
title Analgesic effect of preoperative versus intraoperative dexamethasone after laparoscopic cholecystectomy with multimodal analgesia
title_full Analgesic effect of preoperative versus intraoperative dexamethasone after laparoscopic cholecystectomy with multimodal analgesia
title_fullStr Analgesic effect of preoperative versus intraoperative dexamethasone after laparoscopic cholecystectomy with multimodal analgesia
title_full_unstemmed Analgesic effect of preoperative versus intraoperative dexamethasone after laparoscopic cholecystectomy with multimodal analgesia
title_short Analgesic effect of preoperative versus intraoperative dexamethasone after laparoscopic cholecystectomy with multimodal analgesia
title_sort analgesic effect of preoperative versus intraoperative dexamethasone after laparoscopic cholecystectomy with multimodal analgesia
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219778/
https://www.ncbi.nlm.nih.gov/pubmed/22110885
http://dx.doi.org/10.4097/kjae.2011.61.4.315
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