Anaplastic lymphoma kinase (ALK) inhibitor response in neuroblastoma is highly correlated with ALK mutation status, ALK mRNA and protein levels

BACKGROUND: In pediatric neuroblastoma (NBL), high anaplastic lymphoma kinase (ALK) levels appear to be correlated with an unfavorable prognosis, regardless of ALK mutation status. This suggests a therapeutic role for ALK inhibitors in NBL patients. We examined the correlation between levels of ALK,...

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Detalles Bibliográficos
Autores principales: Duijkers, Floor A. M., Gaal, José, Meijerink, Jules P. P., Admiraal, Pieter, Pieters, Rob, de Krijger, Ronald R., van Noesel, Max M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2011
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219872/
https://www.ncbi.nlm.nih.gov/pubmed/21625996
http://dx.doi.org/10.1007/s13402-011-0048-2

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