Visualization and Manipulation of Neural Activity in the Developing Vertebrate Nervous System

Neural activity during vertebrate development has been unambiguously shown to play a critical role in sculpting circuit formation and function. Patterned neural activity in various parts of the developing nervous system is thought to modulate neurite outgrowth, axon targeting, and synapse refinement...

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Detalles Bibliográficos
Autores principales: Zhang, Jiayi, Ackman, James B., Dhande, Onkar S., Crair, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219918/
https://www.ncbi.nlm.nih.gov/pubmed/22121343
http://dx.doi.org/10.3389/fnmol.2011.00043
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author Zhang, Jiayi
Ackman, James B.
Dhande, Onkar S.
Crair, Michael C.
author_facet Zhang, Jiayi
Ackman, James B.
Dhande, Onkar S.
Crair, Michael C.
author_sort Zhang, Jiayi
collection PubMed
description Neural activity during vertebrate development has been unambiguously shown to play a critical role in sculpting circuit formation and function. Patterned neural activity in various parts of the developing nervous system is thought to modulate neurite outgrowth, axon targeting, and synapse refinement. The nature and role of patterned neural activity during development has been classically studied with in vitro preparations using pharmacological manipulations. In this review we discuss newly available and developing molecular–genetic tools for the visualization and manipulation of neural activity patterns specifically during development.
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spelling pubmed-32199182011-11-25 Visualization and Manipulation of Neural Activity in the Developing Vertebrate Nervous System Zhang, Jiayi Ackman, James B. Dhande, Onkar S. Crair, Michael C. Front Mol Neurosci Neuroscience Neural activity during vertebrate development has been unambiguously shown to play a critical role in sculpting circuit formation and function. Patterned neural activity in various parts of the developing nervous system is thought to modulate neurite outgrowth, axon targeting, and synapse refinement. The nature and role of patterned neural activity during development has been classically studied with in vitro preparations using pharmacological manipulations. In this review we discuss newly available and developing molecular–genetic tools for the visualization and manipulation of neural activity patterns specifically during development. Frontiers Research Foundation 2011-11-18 /pmc/articles/PMC3219918/ /pubmed/22121343 http://dx.doi.org/10.3389/fnmol.2011.00043 Text en Copyright © 2011 Zhang, Ackman, Dhande and Crair. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Neuroscience
Zhang, Jiayi
Ackman, James B.
Dhande, Onkar S.
Crair, Michael C.
Visualization and Manipulation of Neural Activity in the Developing Vertebrate Nervous System
title Visualization and Manipulation of Neural Activity in the Developing Vertebrate Nervous System
title_full Visualization and Manipulation of Neural Activity in the Developing Vertebrate Nervous System
title_fullStr Visualization and Manipulation of Neural Activity in the Developing Vertebrate Nervous System
title_full_unstemmed Visualization and Manipulation of Neural Activity in the Developing Vertebrate Nervous System
title_short Visualization and Manipulation of Neural Activity in the Developing Vertebrate Nervous System
title_sort visualization and manipulation of neural activity in the developing vertebrate nervous system
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219918/
https://www.ncbi.nlm.nih.gov/pubmed/22121343
http://dx.doi.org/10.3389/fnmol.2011.00043
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