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Wld(S) Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis

OBJECTIVE: Wld(S) (Wallerian degeneration slow), a fusion protein from a spontaneous mutation containing full-length nicotinamide mononucleotide adenylyltransferase 1, has NAD biosynthesis activity and protects axon from degeneration robustly. NAD biosynthesis is also implicated in insulin secretion...

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Detalles Bibliográficos
Autores principales:	Wu, Jingxia, Zhang, Fang, Yan, Menghong, Wu, Dongmei, Yu, Qiujing, Zhang, Yi, Zhou, Ben, McBurney, Michael W., Zhai, Qiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219932/ https://www.ncbi.nlm.nih.gov/pubmed/21998399 http://dx.doi.org/10.2337/db11-0232

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